BACKGROUND: Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats (Psammomys obesus, Israeli sand rat) and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM), and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. METHODS: Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction (PCR), Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay (ELISA). RESULTS: SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. CONCLUSIONS: SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.
BACKGROUND: Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabeticrats (Psammomys obesus, Israeli sand rat) and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM), and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. METHODS:Human omental adipose tissues from ten cases of type 2 diabeticpatients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction (PCR), Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay (ELISA). RESULTS:SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. CONCLUSIONS:SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.
Authors: Lucia A Seale; Ann C Hashimoto; Suguru Kurokawa; Christy L Gilman; Ali Seyedali; Frederick P Bellinger; Arjun V Raman; Marla J Berry Journal: Mol Cell Biol Date: 2012-08-13 Impact factor: 4.272
Authors: F B Filippin-Monteiro; E M de Oliveira; S Sandri; F H Knebel; R C Albuquerque; A Campa Journal: Int J Obes (Lond) Date: 2011-10-11 Impact factor: 5.095
Authors: Maja Olsson; Bob Olsson; Peter Jacobson; Dag S Thelle; Johan Björkegren; Andrew Walley; Philippe Froguel; Lena M S Carlsson; Kajsa Sjöholm Journal: Metabolism Date: 2011-01 Impact factor: 8.694