[Significance of Forkhead Box m1b (Foxm1b) gene in cell proliferation and carcinogenesis].

Forkhead Box m1b (Foxm1b) is a subtype of the Fox transcription factor family. It is detected in all proliferative cells, but disappears when cells enter into their terminal differentiation phase. Foxm1b is closely related to hepatocellular growth, mainly through inhibiting cyclin-dependent kinase (CDK) inhibitors to influence cell proliferation. It also participates in growth hormone (GH) mediated cell multiplication, but does not induce tumors. The expression of Foxm1b has been observed in many tumor cell lines and malignant tumors, indicating that it might be an essential proto-oncogene in carcinogenesis. Furthermore, Foxm1b may take part in liver regeneration after hepatectomy, hepatic failure and liver transplantation. Foxm1b is a new potential target for the treatment human hepatic cell carcinoma (HCC).