Literature DB >> 18709567

U-shaped dose response in behavioral pharmacology: historical foundations.

Edward J Calabrese1.   

Abstract

This article assesses the historical foundations of U-shaped dose-responses in behavioral pharmacology and toxicology with particular emphasis on schedules of reinforcement. Quantitative features of the drug dose response, which are consistent with the hormetic dose response model, are detailed along with possible mechanistic foundations to account for low-dose stimulation and high-dose inhibition responses. The article provides a reinterpretation of the biphasic dose response in the fixed interval (FI) schedule of reinforcement.

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Year:  2008        PMID： 18709567     DOI： 10.1080/10408440802026307

Source DB:  PubMed          Journal:  Crit Rev Toxicol        ISSN： 1040-8444            Impact factor:   5.635


  14 in total

1.  Dose-dependent effects of alcohol injections on omission-contingency learning have an inverted-U pattern.

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3.  Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?

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4.  The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration.

Authors:  Rachel D Penrod; Morgane Thomsen; Makoto Taniguchi; Yuhong Guo; Christopher W Cowan; Laura N Smith
Journal:  Pharmacol Biochem Behav       Date:  2019-11-01       Impact factor: 3.533

5.  Dose preference and dose escalation in extended-access cocaine self-administration in Fischer and Lewis rats.

Authors:  Roberto Picetti; Ann Ho; Eduardo R Butelman; Mary Jeanne Kreek
Journal:  Psychopharmacology (Berl)       Date:  2010-06-19       Impact factor: 4.530

6.  The hormetic morphogen theory of curvature and the morphogenesis and pathology of tubular and other curved structures.

Authors:  Egil Fosslien
Journal:  Dose Response       Date:  2009-10-16       Impact factor: 2.658

Review 7.  Quantifying reinforcement value and demand for psychoactive substances in humans.

Authors:  Adrienne J Heinz; Todd C Lilje; Jon D Kassel; Harriet de Wit
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8.  Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine.

Authors:  Nicholas E Clifton; Nadège Morisot; Sylvie Girardon; Mark J Millan; Florence Loiseau
Journal:  Psychopharmacology (Berl)       Date:  2012-09-16       Impact factor: 4.530

Review 9.  Factors mediating pain-related risk for opioid use disorder.

Authors:  Arbi Nazarian; S Stevens Negus; Thomas J Martin
Journal:  Neuropharmacology       Date:  2021-01-30       Impact factor: 5.250

10.  Homeopathic Doses of Gelsemium sempervirens Improve the Behavior of Mice in Response to Novel Environments.

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