CONTEXT: International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI). OBJECTIVE: To undertake a systematic review and meta-analysis of randomised placebo-controlled trials of oxygen therapy in MI. DATA SOURCES: Medline, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, EMBASE and CINHAL. STUDY SELECTION: Randomised placebo-controlled trials of oxygen therapy in MI. DATA EXTRACTION: The primary clinical outcome was mortality. RESULTS: Two of 51 potential studies met the inclusion criteria. The one study with substantive clinical outcome data reported that in uncomplicated MI, high-flow oxygen was associated with a non-significant increased risk of death (risk ratio 2.9, 95% CI 0.8 to 10.3, p = 0.08) and a greater serum aspartate aminotransferase level (difference 19.2 IU/ml, 95% CI 0 to 38.4, p = 0.05) than room air. CONCLUSION: The limited evidence that does exist suggests that the routine use of high-flow oxygen in uncomplicated MI may result in a greater infarct size and possibly increase the risk of mortality.
CONTEXT: International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI). OBJECTIVE: To undertake a systematic review and meta-analysis of randomised placebo-controlled trials of oxygen therapy in MI. DATA SOURCES: Medline, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, EMBASE and CINHAL. STUDY SELECTION: Randomised placebo-controlled trials of oxygen therapy in MI. DATA EXTRACTION: The primary clinical outcome was mortality. RESULTS: Two of 51 potential studies met the inclusion criteria. The one study with substantive clinical outcome data reported that in uncomplicated MI, high-flow oxygen was associated with a non-significant increased risk of death (risk ratio 2.9, 95% CI 0.8 to 10.3, p = 0.08) and a greater serum aspartate aminotransferase level (difference 19.2 IU/ml, 95% CI 0 to 38.4, p = 0.05) than room air. CONCLUSION: The limited evidence that does exist suggests that the routine use of high-flow oxygen in uncomplicated MI may result in a greater infarct size and possibly increase the risk of mortality.
Authors: João D Mattos; Monique O Campos; Marcos P Rocha; Daniel E Mansur; Helena N M Rocha; Vinicius P Garcia; Gabriel Batista; Thiago S Alvares; Gustavo V Oliveira; Mônica V Souza; Rogério L R Videira; Natalia G Rocha; Niels H Secher; Antonio C L Nóbrega; Igor A Fernandes Journal: J Physiol Date: 2018-12-26 Impact factor: 5.182
Authors: Brian M Fuller; Nicholas M Mohr; Christopher N Miller; Andrew R Deitchman; Brian J Levine; Nicole Castagno; Elizabeth C Hassebroek; Adam Dhedhi; Nicholas Scott-Wittenborn; Edward Grace; Courtney Lehew; Marin H Kollef Journal: Chest Date: 2015-08 Impact factor: 9.410
Authors: Garry M Steil; Olive S Eckstein; Julie Caplow; Michael S D Agus; Brian K Walsh; Jackson Wong Journal: J Clin Monit Comput Date: 2011-06-21 Impact factor: 2.502