Literature DB >> 18708273

Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties.

Gabriela Laura Almajan1, Stefania-Felicia Barbuceanu, Eva-Ruxandra Almajan, Constantin Draghici, Gabriel Saramet.   

Abstract

A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X=H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.

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Year:  2008        PMID： 18708273     DOI： 10.1016/j.ejmech.2008.07.003

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  A High Strength Self-Healable Antibacterial and Anti-Inflammatory Supramolecular Polymer Hydrogel.

Authors:  Hongbo Wang; Hui Zhu; Weigui Fu; Yinyu Zhang; Bing Xu; Fei Gao; Zhiqiang Cao; Wenguang Liu
Journal:  Macromol Rapid Commun       Date:  2017-03-08       Impact factor: 5.734

Review 2.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

3.  Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity.

Authors:  Tomasz Plech; Monika Wujec; Magdalena Majewska; Urszula Kosikowska; Anna Malm
Journal:  Med Chem Res       Date:  2012-09-29       Impact factor: 1.965

4.  Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities.

Authors:  Serap Basoglu; Serdar Ulker; Sengul Alpay-Karaoglu; Neslihan Demirbas
Journal:  Med Chem Res       Date:  2013-12-29       Impact factor: 1.965

5.  Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols.

Authors:  Ebtehal S Al-Abdullah; Hanadi H Asiri; Siham Lahsasni; Elsayed E Habib; Tarek M Ibrahim; Ali A El-Emam
Journal:  Drug Des Devel Ther       Date:  2014-05-12       Impact factor: 4.162

6.  1-[4-Bromo-2-(tri-fluoro-meth-oxy)phen-yl]-3-methyl-1H-1,2,4-triazole.

Authors:  C Sandeep; Basavaraj Padmashali; P A Suchetan; Rashmi S Kulkarni
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-05-10
  6 in total

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