| Literature DB >> 18708088 |
Abstract
The preparation and characterization of nitric oxide (NO)-releasing chitosan-folate conjugates were reported. The secondary amine chitosan-folate conjugates exhibited a high storage capacity for NO (up to 84.3 nmol NO/mg) (when the graft rate of folate was 12.5%), greatly increasing the "payload" of released NO with the graft rate of folate increasing. The NO release durations (12h) observed for secondary amine the chitosan-folate conjugates with the high graft rate (12.5%) were largerly shorter compared to O2-protected diazeniumliolates with BrCH2CH3 (24 h), thus illustrating a macromolecular effect on NO release kinetics.Entities:
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Year: 2008 PMID： 18708088 DOI： 10.1016/j.ijbiomac.2008.07.016
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953