Literature DB >> 18707543

Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2.

Sarah A Keim1, Keith R Johnson, Margaret J Wheelock, James K Wahl.   

Abstract

Abstract Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.

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Year:  2008        PMID： 18707543      PMCID： PMC3186698          DOI： 10.1089/hyb.2008.0020

Source DB:  PubMed          Journal:  Hybridoma (Larchmt)        ISSN： 1554-0014


  22 in total

1.  Molecular interactions between desmosomal cadherins.

Authors:  Shabih-e-Hassnain Syed; Brian Trinnaman; Stephen Martin; Sarah Major; Jon Hutchinson; Anthony I Magee
Journal:  Biochem J       Date:  2002-03-01       Impact factor: 3.857

2.  N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane.

Authors:  James K Wahl; Young J Kim; Janet M Cullen; Keith R Johnson; Margaret J Wheelock
Journal:  J Biol Chem       Date:  2003-02-25       Impact factor: 5.157

Review 3.  Desmosomal cadherins.

Authors:  David R Garrod; Anita J Merritt; Zhuxiang Nie
Journal:  Curr Opin Cell Biol       Date:  2002-10       Impact factor: 8.382

Review 4.  Working out the strength and flexibility of desmosomes.

Authors:  Spiro Getsios; Arthur C Huen; Kathleen J Green
Journal:  Nat Rev Mol Cell Biol       Date:  2004-04       Impact factor: 94.444

Review 5.  Hyper-adhesion: a new concept in cell-cell adhesion.

Authors:  David Garrod; Tomomi E Kimura
Journal:  Biochem Soc Trans       Date:  2008-04       Impact factor: 5.407

6.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 7.  The ins and outs of E-cadherin trafficking.

Authors:  David M Bryant; Jennifer L Stow
Journal:  Trends Cell Biol       Date:  2004-08       Impact factor: 20.808

8.  Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin.

Authors:  M Ozawa; R Kemler
Journal:  J Cell Biol       Date:  1990-10       Impact factor: 10.539

9.  A novel role for p120 catenin in E-cadherin function.

Authors:  Renee C Ireton; Michael A Davis; Jolanda van Hengel; Deborah J Mariner; Kirk Barnes; Molly A Thoreson; Panos Z Anastasiadis; Linsey Matrisian; Linda M Bundy; Linda Sealy; Barbara Gilbert; Frans van Roy; Albert B Reynolds
Journal:  J Cell Biol       Date:  2002-11-11       Impact factor: 10.539

10.  Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome.

Authors:  L A Nilles; D A Parry; E E Powers; B D Angst; R M Wagner; K J Green
Journal:  J Cell Sci       Date:  1991-08       Impact factor: 5.285
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  8 in total

1.  Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions.

Authors:  Hongjie Wang; ZongYi Li; Roma Yumul; Stephanie Lara; Akseli Hemminki; Pascal Fender; André Lieber
Journal:  J Virol       Date:  2011-04-27       Impact factor: 5.103

2.  Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes.

Authors:  Andrew M Overmiller; Jennifer A Pierluissi; Peter J Wermuth; Sami Sauma; Ubaldo Martinez-Outschoorn; Madalina Tuluc; Adam Luginbuhl; Joseph Curry; Larry A Harshyne; James K Wahl; Andrew P South; Mỹ G Mahoney
Journal:  FASEB J       Date:  2017-04-24       Impact factor: 5.191

3.  Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

Authors:  Hongjie Wang; Zong-Yi Li; Ying Liu; Jonas Persson; Ines Beyer; Thomas Möller; Dilara Koyuncu; Max R Drescher; Robert Strauss; Xiao-Bing Zhang; James K Wahl; Nicole Urban; Charles Drescher; Akseli Hemminki; Pascal Fender; André Lieber
Journal:  Nat Med       Date:  2010-12-12       Impact factor: 53.440

4.  A role for caveolin-1 in desmoglein binding and desmosome dynamics.

Authors:  D Brennan; S Peltonen; A Dowling; W Medhat; K J Green; J K Wahl; F Del Galdo; M G Mahoney
Journal:  Oncogene       Date:  2011-08-15       Impact factor: 9.867

5.  Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.

Authors:  Donna M Brennan-Crispi; Claudia Hossain; Joya Sahu; Mary Brady; Natalia A Riobo; Mỹ G Mahoney
Journal:  Oncotarget       Date:  2015-04-20

6.  Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion.

Authors:  Abhilasha Gupta; Daniela Nitoiu; Donna Brennan-Crispi; Sankar Addya; Natalia A Riobo; David P Kelsell; Mỹ G Mahoney
Journal:  PLoS One       Date:  2015-03-18       Impact factor: 3.240

7.  c-Src/Cav1-dependent activation of the EGFR by Dsg2.

Authors:  Andrew M Overmiller; Kathleen P McGuinn; Brett J Roberts; Felicia Cooper; Donna M Brennan-Crispi; Takahiro Deguchi; Sirkku Peltonen; James K Wahl; Mỹ G Mahoney
Journal:  Oncotarget       Date:  2016-06-21

8.  In vitro functional analyses of arrhythmogenic right ventricular cardiomyopathy-associated desmoglein-2-missense variations.

Authors:  Anna Gaertner; Baerbel Klauke; Ines Stork; Karsten Niehaus; Gesa Niemann; Jan Gummert; Hendrik Milting
Journal:  PLoS One       Date:  2012-10-10       Impact factor: 3.240
  8 in total

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