| Literature DB >> 18707091 |
Naoki Teno1, Keiichi Masuya, Takeru Ehara, Takatoshi Kosaka, Takahiro Miyake, Osamu Irie, Yuko Hitomi, Naoko Matsuura, Ichiro Umemura, Genji Iwasaki, Hiroaki Fukaya, Kazuhiro Toriyama, Noriko Uchiyama, Kazuhiko Nonomura, Ikuo Sugiyama, Motohiko Kometani.
Abstract
On the basis of the pyrrolopyrimidine core structure that was previously discovered, cathepsin K inhibitors having a spiro amine at the P3 have been explored to enhance the target, bone marrow, tissue distribution. Several spiro structures were identified with improved distribution toward bone marrow. The representative inhibitor 7 of this series revealed in vivo reduction in C-terminal telopeptide of type I collagen in rats and monkeys.Entities:
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Year: 2008 PMID： 18707091 DOI： 10.1021/jm800626a
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446