| Literature DB >> 18706939 |
Egor Prokhortchouk1, Pierre-Antoine Defossez.
Abstract
In this review, we will provide a brief reminder of epigenetic phenomena in general, and DNA methylation in particular. We will then underline the characteristics of the in vivo organization of the genome that limit the applicability of in vitro results. We will use several examples to point out the connections between DNA methylation and nuclear architecture. Finally, we will outline some of the hopes and challenges for future research in the field. The study of DNA methylation, its effectors, and its roles, illustrates the complementarity of in vitro approaches and cell biology.Mesh：
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Year: 2008 PMID： 18706939 DOI： 10.1016/j.bbamcr.2008.07.015
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002