| Literature DB >> 18706810 |
Erik A Jensen1, Benjamin D Allen, Yoshito Kishi, Daniel J O'Leary.
Abstract
Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH(2)C(5') (psi) carbon-carbon bond, which is energetically preferred over the alternate CH(2)N(3) (phi) carbon-nitrogen bond rotation.Entities:
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Year: 2008 PMID： 18706810 PMCID： PMC2590868 DOI： 10.1016/j.bmcl.2008.07.113
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823