| Literature DB >> 18706461 |
Yuan-Pin Huang1, Tsuey-Li Lin, Chuan-Yi Kuo, Miao-Wen Lin, Ching-Yuan Yao, Hui-Wen Liao, Li-Ching Hsu, Chen-Fu Yang, Jyh-Yuan Yang, Pei-Jer Chen, Ho-Sheng Wu.
Abstract
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B; however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan.Entities:
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Year: 2008 PMID： 18706461 DOI： 10.1016/j.virusres.2008.07.015
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303