| Literature DB >> 18706320 |
Frédéric Laure1, Phila Raharivelomanana, Jean-François Butaud, Jean-Pierre Bianchini, Emile M Gaydou.
Abstract
Various pyranocoumarins, calophyllolide, inophyllums B, C, G(1), G(2) and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg(-1), respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs.Entities:
Mesh:
Substances:
Year: 2008 PMID: 18706320 DOI: 10.1016/j.aca.2008.06.046
Source DB: PubMed Journal: Anal Chim Acta ISSN: 0003-2670 Impact factor: 6.558