BACKGROUND: Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established. METHODS: The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported. RESULTS: Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies. CONCLUSIONS: The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality. (c) 2008 Wiley Periodicals, Inc.
BACKGROUND: Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established. METHODS: The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported. RESULTS: Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies. CONCLUSIONS: The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality. (c) 2008 Wiley Periodicals, Inc.
Authors: Lisa A Kottschade; Travis E Grotz; Roxana S Dronca; Diva R Salomao; Jose S Pulido; Nabil Wasif; James W Jakub; Sanjay P Bagaria; Riten Kumar; Judith S Kaur; Shane Y Morita; Steven L Moran; Jesse T Nguyen; Emily C Nguyen; Jennifer L Hand; Lori A Erickson; Jerry D Brewer; Christian L Baum; Robert C Miller; David L Swanson; Val Lowe; Svetomir N Markovic Journal: Am J Clin Oncol Date: 2014-12 Impact factor: 2.339
Authors: Hong Gang Liu; Max Xiangtian Kong; Qian Yao; Shu Yi Wang; Robert Shibata; Herman Yee; Frank Martiniuk; Beverly Y Wang Journal: Head Neck Pathol Date: 2012-06-27
Authors: Fernando López; Juan P Rodrigo; Antonio Cardesa; Asterios Triantafyllou; Kenneth O Devaney; William M Mendenhall; Missak Haigentz; Primož Strojan; Phillip K Pellitteri; Carol R Bradford; Ashok R Shaha; Jennifer L Hunt; Remco de Bree; Robert P Takes; Alessandra Rinaldo; Alfio Ferlito Journal: Head Neck Date: 2015-05-22 Impact factor: 3.147