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Literature DB >> 18704769

P2X7 receptors in oligodendrocytes: a novel target for neuroprotection.

Abstract

Intense ATP signaling through P2X7 purinergic receptors can lead to excitotoxicity, a feature which initiates neuronal demise in experimental paradigms relevant to ischemia and to traumatic injury. In addition, recent data provide evidence that oligodendrocytes also express P2X7 receptors that are activated under experimental pathological conditions involving white matter demise. Thus, this receptor subtype is a promising target for the development of new drugs to prevent white matter damage in acute and chronic diseases.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18704769 DOI： 10.1007/s12035-008-8028-x

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

49 in total

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Authors: B S Khakh
Journal: Nat Rev Neurosci Date: 2001-03 Impact factor: 34.870

2. Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems.

Authors: S A Deuchars; L Atkinson; R E Brooke; H Musa; C J Milligan; T F Batten; N J Buckley; S H Parson; J Deuchars
Journal: J Neurosci Date: 2001-09-15 Impact factor: 6.167

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Authors: F Di Virgilio; J M Sanz; P Chiozzi; S Falzoni
Journal: Prog Brain Res Date: 1999 Impact factor: 2.453

4. Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes.

Authors: Lanfen Chen; Celia F Brosnan
Journal: J Immunol Date: 2006-03-01 Impact factor: 5.422

5. Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy.

Authors: Grant R J Gordon; Dinara V Baimoukhametova; Sarah A Hewitt; W R A Kosala J S Rajapaksha; Thomas E Fisher; Jaideep S Bains
Journal: Nat Neurosci Date: 2005-07-03 Impact factor: 24.884

Review 6. P2X receptors as cell-surface ATP sensors in health and disease.

Authors: Baljit S Khakh; R Alan North
Journal: Nature Date: 2006-08-03 Impact factor: 49.962

7. A universal scaling law between gray matter and white matter of cerebral cortex.

Authors: K Zhang; T J Sejnowski
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

8. A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.

Authors: Giulio Cabrini; Simonetta Falzoni; Sylvia L Forchap; Patrizia Pellegatti; Alessandra Balboni; Paola Agostini; Antonio Cuneo; Gianluigi Castoldi; O Roberto Baricordi; Francesco Di Virgilio
Journal: J Immunol Date: 2005-07-01 Impact factor: 5.422

Review 9. Liaisons dangereuses: P2X(7) and the inflammasome.

Authors: Francesco Di Virgilio
Journal: Trends Pharmacol Sci Date: 2007-08-10 Impact factor: 14.819

Review 10. P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system.

Authors: Greg James; Arthur M Butt
Journal: Eur J Pharmacol Date: 2002-07-05 Impact factor: 4.432

27 in total

1. Targeting ion channels for the treatment of autoimmune neuroinflammation.

Authors: Stefan Bittner; Sven G Meuth
Journal: Ther Adv Neurol Disord Date: 2013-09 Impact factor: 6.570

Review 2. Purinoceptors on neuroglia.

Authors: Alexei Verkhratsky; Alexei Verkhrasky; Oleg A Krishtal; Geoffrey Burnstock
Journal: Mol Neurobiol Date: 2009-03-13 Impact factor: 5.590

Review 3. Novel therapeutic approaches in multiple system atrophy.

Authors: Jose-Alberto Palma; Horacio Kaufmann
Journal: Clin Auton Res Date: 2014-06-14 Impact factor: 4.435

Review 4. White matter damage after traumatic brain injury: A role for damage associated molecular patterns.

Authors: Molly Braun; Kumar Vaibhav; Nancy M Saad; Sumbul Fatima; John R Vender; Babak Baban; Md Nasrul Hoda; Krishnan M Dhandapani
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2017-05-19 Impact factor: 5.187

5. P2Y12 receptor expression is a critical determinant of functional responsiveness to ATX's MORFO domain.

Authors: Jameel Dennis; Magdalena K Morgan; Martin R Graf; Babette Fuss
Journal: Purinergic Signal Date: 2011-12-04 Impact factor: 3.765

Review 6. Neuroglial roots of neurodegenerative diseases?

Authors: José Julio Rodríguez; Alexei Verkhratsky
Journal: Mol Neurobiol Date: 2010-12-15 Impact factor: 5.590

7. P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.

Authors: Tobias Engel; Alba Jimenez-Pacheco; Maria Teresa Miras-Portugal; Miguel Diaz-Hernandez; David C Henshall
Journal: Int J Physiol Pathophysiol Pharmacol Date: 2012-12-26

Review 8. Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.

Authors: Scott A Friedle; Marjorie A Curet; Jyoti J Watters
Journal: Recent Pat CNS Drug Discov Date: 2010-01

9. P2X receptors in neuroglia.

Authors: Alexei Verkhratsky; Yuri Pankratov; Ulyana Lalo; Maiken Nedergaard
Journal: Wiley Interdiscip Rev Membr Transp Signal Date: 2012

Review 10. Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis.

Authors: Ragnhildur T Káradóttir; Chay T Kuo
Journal: Annu Rev Neurosci Date: 2018-04-04 Impact factor: 12.449