OBJECTIVE: To investigate the relation of physical activity to head and neck cancer. METHODS: We prospectively examined the association between physical activity and head and neck cancer in 487,732 men and women, who, at baseline in 1995-1996, were 50-71 years old and free of cancer and emphysema. Follow-up occurred through 31 December 2003. RESULTS: During follow-up, 1,249 participants developed head and neck cancer, of which 42.0%, 18.9%, and 32.5% were located in the oral cavity, pharynx, and larynx, respectively. In analyses adjusted for age and gender, the relative risks (RR) of head and neck cancer for increasing frequency of physical activity (0, < 1, 1-2, 3-4, and >or=5 times per week) were 1.0 (reference), 0.76, 0.66, 0.57, and 0.62 (95% CI = 0.52-0.74), respectively (p for trend < 0.001). After multivariate adjustment including smoking, the relation was attenuated and became statistically non-significant (RR comparing extreme physical activity categories = 0.89, 95% CI = 0.74-1.06; p for trend = 0.272). In analyses of head and neck cancer subtypes, the corresponding RRs for cancers of the oral cavity, pharynx, and larynx were 0.98 (95% CI = 0.75-1.29), 0.70 (95% CI = 0.45-1.08), and 0.82 (95% CI = 0.59-1.13), respectively. CONCLUSIONS: Our findings suggest that physical activity is unlikely to play an important role in the prevention of head and neck cancer.
OBJECTIVE: To investigate the relation of physical activity to head and neck cancer. METHODS: We prospectively examined the association between physical activity and head and neck cancer in 487,732 men and women, who, at baseline in 1995-1996, were 50-71 years old and free of cancer and emphysema. Follow-up occurred through 31 December 2003. RESULTS: During follow-up, 1,249 participants developed head and neck cancer, of which 42.0%, 18.9%, and 32.5% were located in the oral cavity, pharynx, and larynx, respectively. In analyses adjusted for age and gender, the relative risks (RR) of head and neck cancer for increasing frequency of physical activity (0, < 1, 1-2, 3-4, and >or=5 times per week) were 1.0 (reference), 0.76, 0.66, 0.57, and 0.62 (95% CI = 0.52-0.74), respectively (p for trend < 0.001). After multivariate adjustment including smoking, the relation was attenuated and became statistically non-significant (RR comparing extreme physical activity categories = 0.89, 95% CI = 0.74-1.06; p for trend = 0.272). In analyses of head and neck cancer subtypes, the corresponding RRs for cancers of the oral cavity, pharynx, and larynx were 0.98 (95% CI = 0.75-1.29), 0.70 (95% CI = 0.45-1.08), and 0.82 (95% CI = 0.59-1.13), respectively. CONCLUSIONS: Our findings suggest that physical activity is unlikely to play an important role in the prevention of head and neck cancer.
Authors: Alexis J Platek; Rikki A Cannioto; John Lewis Etter; Jae Kim; Janine M Joseph; Nicholas R Gulati; Kristina L Schmitt; Emily Callahan; Edgar Khachatryan; Ryan Nagy; Albina Minlikeeva; J Brian Szender; Anurag K Singh; Iris Danziger; Kirsten B Moysich Journal: Eur Arch Otorhinolaryngol Date: 2017-08-05 Impact factor: 2.503
Authors: Alpa V Patel; Christine M Friedenreich; Steven C Moore; Sandra C Hayes; Julie K Silver; Kristin L Campbell; Kerri Winters-Stone; Lynn H Gerber; Stephanie M George; Janet E Fulton; Crystal Denlinger; G Stephen Morris; Trisha Hue; Kathryn H Schmitz; Charles E Matthews Journal: Med Sci Sports Exerc Date: 2019-11 Impact factor: 5.411