Literature DB >> 187045

Inhibition of adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide PGH2.

R R Gorman, M Hamberg, B Samuelsson.   

Abstract

The prostaglandin endoperoxide PGH2 antagonized basal and hormone-stimulated adenylate cyclase activity in an adipocyte ghost preparation. The inhibition was readily reversible, and demonstrable on initial rates of cAMP synthesis. It is suggested that PGH2 may be an endogenous feedback regulator of lipolysis in adipose tissue.

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Year:  1976        PMID: 187045

Source DB:  PubMed          Journal:  Adv Prostaglandin Thromboxane Res        ISSN: 0361-5952


  2 in total

1.  Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: studies in vivo.

Authors:  J K Greenacre; M E Conolly
Journal:  Br J Clin Pharmacol       Date:  1978-03       Impact factor: 4.335

2.  In vitro and in vivo effects of ethanol on the formation of endoperoxide metabolites in rat platelets.

Authors:  D H Hwang; P LeBlanc; P Chanmugan
Journal:  Lipids       Date:  1981-08       Impact factor: 1.880

  2 in total

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