BACKGROUND: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a genetically engineered protein which recruits bone-forming cells to the surgical area and converts local cells to bone. In clinical studies, rhBMP-2 successfully enhanced anterior/posterior spinal fusions in adult humans without bone grafts. Efficacy in paediatric spinal fusion is not yet reported. METHODS: We describe the surgical technique and results in a 2-year-old girl with unstable C1-2 cervical spine injury who underwent non-metal-instrumented C1/C2 posterior spinal fusion using rhBMP-2 applied to an absorbable collagen sponge (ACS) matrix. RESULTS: Radiologically verifiable bony fusion began at 3 weeks. Within 8 weeks solid C1-C2 spinal fusion was confirmed by CT scan. There was no evidence of spinal canal encroachment and no adverse effects related to the rhBMP-2/ACS-carrier matrix. CONCLUSION: rhBMP-2 enhanced posterior cervical fusion at an impressive rate in a very young child. This finding is encouraging both to effectiveness and speed. However, with all new developments, we highlight the need for further experience and longer follow-up in children. (c) 2008 S. Karger AG, Basel.
BACKGROUND: Recombinant humanbone morphogenetic protein-2 (rhBMP-2) is a genetically engineered protein which recruits bone-forming cells to the surgical area and converts local cells to bone. In clinical studies, rhBMP-2 successfully enhanced anterior/posterior spinal fusions in adult humans without bone grafts. Efficacy in paediatric spinal fusion is not yet reported. METHODS: We describe the surgical technique and results in a 2-year-old girl with unstable C1-2 cervical spine injury who underwent non-metal-instrumented C1/C2 posterior spinal fusion using rhBMP-2 applied to an absorbable collagen sponge (ACS) matrix. RESULTS: Radiologically verifiable bony fusion began at 3 weeks. Within 8 weeks solid C1-C2 spinal fusion was confirmed by CT scan. There was no evidence of spinal canal encroachment and no adverse effects related to the rhBMP-2/ACS-carrier matrix. CONCLUSION: rhBMP-2 enhanced posterior cervical fusion at an impressive rate in a very young child. This finding is encouraging both to effectiveness and speed. However, with all new developments, we highlight the need for further experience and longer follow-up in children. (c) 2008 S. Karger AG, Basel.
Authors: Sebastian J Winocour; Erica Y Xue; Michael A Bohl; Farrokh Farrokhi; Matthew J Davis; Amjed Abu-Ghname; Alexander E Ropper; Edward M Reece Journal: Semin Plast Surg Date: 2021-05-10 Impact factor: 2.314
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Authors: Guirish A Solanki; Kenneth W Martin; Mary C Theroux; Christina Lampe; Klane K White; Renée Shediac; Christian G Lampe; Michael Beck; William G Mackenzie; Christian J Hendriksz; Paul R Harmatz Journal: J Inherit Metab Dis Date: 2013-02-06 Impact factor: 4.982