INTRODUCTION: Central nervous system tumours represent 20% of all childhood cancers, and are the second most common group of neoplasms after leukaemias. OBJECTIVE: To describe epidemiological characteristics of central nervous system tumours in a paediatric Tunisian population. PATIENTS AND METHODS: A retrospective study of 492 childhood central nervous system tumours operated between 1990 and 2004 was undertaken. We investigated the age-related location, gender distribution and the histology of all tumours, and adopted the latest WHO classification (2007) in grouping all the tumours. RESULTS: There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal. Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial. The median age at diagnosis was 8 years, with a male:female ratio of 1.14:1. Low-grade tumours (WHO I/II) constituted 67.3% of all lesions and the rest (32.7%) were high-grade tumours (WHO III/IV). The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%). The overall 5-year survival rate was 45% with a mean follow-up period of 36 months. CONCLUSION: In our patient population, the incidence and distribution of central nervous system tumours were similar to those reported in literature. Overall survival rates varied according to tumour location and histopathology. (c) 2008 S. Karger AG, Basel.
INTRODUCTION:Central nervous system tumours represent 20% of all childhood cancers, and are the second most common group of neoplasms after leukaemias. OBJECTIVE: To describe epidemiological characteristics of central nervous system tumours in a paediatric Tunisian population. PATIENTS AND METHODS: A retrospective study of 492 childhood central nervous system tumours operated between 1990 and 2004 was undertaken. We investigated the age-related location, gender distribution and the histology of all tumours, and adopted the latest WHO classification (2007) in grouping all the tumours. RESULTS: There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal. Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial. The median age at diagnosis was 8 years, with a male:female ratio of 1.14:1. Low-grade tumours (WHO I/II) constituted 67.3% of all lesions and the rest (32.7%) were high-grade tumours (WHO III/IV). The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%). The overall 5-year survival rate was 45% with a mean follow-up period of 36 months. CONCLUSION: In our patient population, the incidence and distribution of central nervous system tumours were similar to those reported in literature. Overall survival rates varied according to tumour location and histopathology. (c) 2008 S. Karger AG, Basel.
Authors: Mehdi Karkouri; Sadia Zafad; Mohammed Khattab; Noureddine Benjaafar; Hanan El Kacemi; Sana Sefiani; Fouad Kettani; Subhojit Dey; Amr S Soliman Journal: Childs Nerv Syst Date: 2010-02-24 Impact factor: 1.475
Authors: M Mohammed Ali Elhassan; A Abdalla Mohamedani; H Hussein Mohammed Osman; N Osman Yousif; N Mohamed Elhaj; I Qaddoumi Journal: Childs Nerv Syst Date: 2019-01-04 Impact factor: 1.475
Authors: Vita Stagno; John Mugamba; Peter Ssenyonga; Brian Nsubuga Kaaya; Benjamin C Warf Journal: Childs Nerv Syst Date: 2013-10-17 Impact factor: 1.475
Authors: Dragana Stanić; Danica Grujičić; Tatjana Pekmezović; Jelena Bokun; Marija Popović-Vuković; Dragana Janić; Lejla Paripović; Vesna Ilić; Marija Pudrlja Slović; Rosanda Ilić; Savo Raičević; Milan Sarić; Ivana Mišković; Borko Nidžović; Marina Nikitović Journal: PLoS One Date: 2021-10-26 Impact factor: 3.240