Literature DB >> 18698822

A tandem elimination-cyclization-Suzuki approach: efficient one-pot synthesis of functionalized (Z)-3-(arylmethylene)isoindolin-1-ones.

Caiyun Sun1, Bin Xu.   

Abstract

A novel and efficient one-pot regioselective elimination-cyclization-Suzuki approach was developed to afford (Z)-3-arylmethyleneisoindolin-1-ones in good to excellent yields from easily accessible o-gem-dihalovinylbenzamides and organoboron reagents.

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Year:  2008        PMID： 18698822     DOI： 10.1021/jo801219j

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  In silico and in vivo neuropharmacological evaluation of two γ-amino acid isomers derived from 2,3-disubstituted benzofurans, as ligands of GluN1-GluN2A NMDA receptor.

Authors:  Arturo Coaviche-Yoval; José G Trujillo-Ferrara; Marvin A Soriano-Ursúa; Erik Andrade-Jorge; Luis A Sánchez-Labastida; Héctor Luna; Ricardo Tovar-Miranda
Journal:  Amino Acids       Date:  2021-12-02       Impact factor: 3.520

2.  A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.

Authors:  Keith Smith; Gamal A El-Hiti; Amany S Hegazy; Benson Kariuki
Journal:  Beilstein J Org Chem       Date:  2011-09-06       Impact factor: 2.883

3.  Efficient synthesis of a (Z)-3-methyleneisoindolin-1-one library using Cu(OAc)₂•H₂O/DBU under microwave irradiation.

Authors:  Li Zhang; Yongliang Zhang; Xin Wang; Jingkang Shen
Journal:  Molecules       Date:  2013-01-04       Impact factor: 4.411
  3 in total

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