Literature DB >> 18698475

Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones.

Bas Groenendaal1, Eelco Ruijter, Frans J J de Kanter, Martin Lutz, Anthony L Spek, Romano V A Orru.   

Abstract

Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.

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Year:  2008        PMID: 18698475     DOI: 10.1039/b807138a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  4 in total

1.  Direct Dynamic Protein-Affinity Selection Mass-Spectrometry.

Authors:  Niels Jonker; Henk Lingeman; Hubertus Irth
Journal:  Chromatographia       Date:  2010-05-23       Impact factor: 2.044

2.  Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

Authors:  James D Sunderhaus; Stephen F Martin
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

Review 3.  Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Authors:  Gijs Koopmanschap; Eelco Ruijter; Romano Va Orru
Journal:  Beilstein J Org Chem       Date:  2014-03-04       Impact factor: 2.883

4.  Crystal structures of the two epimers from the unusual thermal C6-epimerization of 5-oxo-1,2,3,5,5a,6,7,9b-octa-hydro-7,9a-ep-oxy-pyrrolo-[2,1-a]iso-indole-6-carb-oxy-lic acid, 5a(RS),6(SR),7(RS),9a(SR),9b(SR) and 5a(RS),6(RS),7(RS),9a(SR),9b(SR).

Authors:  Dmitry S Poplevin; Fedor I Zubkov; Pavel V Dorovatovskii; Yan V Zubavichus; Victor N Khrustalev
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-09-16
  4 in total

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