BACKGROUND: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. DESIGN AND METHODS: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. RESULTS: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. CONCLUSIONS: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.
BACKGROUND: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. DESIGN AND METHODS: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. RESULTS: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. CONCLUSIONS: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.
Authors: Swen Wessendorf; Carsten Schwaenen; Holger Kohlhammer; Dirk Kienle; Gunnar Wrobel; Thomas F E Barth; Michelle Nessling; Peter Möller; Hartmut Döhner; Peter Lichter; Martin Bentz Journal: Oncogene Date: 2003-03-06 Impact factor: 9.867
Authors: Silvia Bea; Andreas Zettl; George Wright; Itziar Salaverria; Philipp Jehn; Victor Moreno; Christof Burek; German Ott; Xavier Puig; Liming Yang; Armando Lopez-Guillermo; Wing C Chan; Timothy C Greiner; Dennis D Weisenburger; James O Armitage; Randy D Gascoyne; Joseph M Connors; Thomas M Grogan; Rita Braziel; Richard I Fisher; Erlend B Smeland; Stein Kvaloy; Harald Holte; Jan Delabie; Richard Simon; John Powell; Wyndham H Wilson; Elaine S Jaffe; Emili Montserrat; Hans-Konrad Muller-Hermelink; Louis M Staudt; Elias Campo; Andreas Rosenwald Journal: Blood Date: 2005-07-26 Impact factor: 22.113
Authors: Sandeep S Dave; Kai Fu; George W Wright; Lloyd T Lam; Philip Kluin; Evert-Jan Boerma; Timothy C Greiner; Dennis D Weisenburger; Andreas Rosenwald; German Ott; Hans-Konrad Müller-Hermelink; Randy D Gascoyne; Jan Delabie; Lisa M Rimsza; Rita M Braziel; Thomas M Grogan; Elias Campo; Elaine S Jaffe; Bhavana J Dave; Warren Sanger; Martin Bast; Julie M Vose; James O Armitage; Joseph M Connors; Erlend B Smeland; Stein Kvaloy; Harald Holte; Richard I Fisher; Thomas P Miller; Emilio Montserrat; Wyndham H Wilson; Manisha Bahl; Hong Zhao; Liming Yang; John Powell; Richard Simon; Wing C Chan; Louis M Staudt Journal: N Engl J Med Date: 2006-06-08 Impact factor: 91.245
Authors: Maria B Karpova; Jacqueline Schoumans; Elisabeth Blennow; Ingemar Ernberg; Jan-Inge Henter; Aleksandr F Smirnov; Magnus Nordenskjöld; Bengt Fadeel Journal: Int J Oncol Date: 2006-03 Impact factor: 5.650
Authors: Michael Hummel; Stefan Bentink; Hilmar Berger; Wolfram Klapper; Swen Wessendorf; Thomas F E Barth; Heinz-Wolfram Bernd; Sergio B Cogliatti; Judith Dierlamm; Alfred C Feller; Martin-Leo Hansmann; Eugenia Haralambieva; Lana Harder; Dirk Hasenclever; Michael Kühn; Dido Lenze; Peter Lichter; Jose Ignacio Martin-Subero; Peter Möller; Hans-Konrad Müller-Hermelink; German Ott; Reza M Parwaresch; Christiane Pott; Andreas Rosenwald; Maciej Rosolowski; Carsten Schwaenen; Benjamin Stürzenhofecker; Monika Szczepanowski; Heiko Trautmann; Hans-Heinrich Wacker; Rainer Spang; Markus Loeffler; Lorenz Trümper; Harald Stein; Reiner Siebert Journal: N Engl J Med Date: 2006-06-08 Impact factor: 91.245
Authors: Mihaela Onciu; Ellen Schlette; Yinmei Zhou; Susana C Raimondi; Francis J Giles; Hagop M Kantarjian; L Jeffrey Medeiros; Raul C Ribeiro; Ching-Hon Pui; John T Sandlund Journal: Cancer Date: 2006-09-01 Impact factor: 6.860
Authors: S Smeland; A K Blystad; S O Kvaløy; I M Ikonomou; J Delabie; G Kvalheim; J Hammerstrøm; G F Lauritzsen; H Holte Journal: Ann Oncol Date: 2004-07 Impact factor: 32.976
Authors: Mark A Lones; Warren G Sanger; Michelle M Le Beau; Nyla A Heerema; Richard Sposto; Sherrie L Perkins; Jonathan Buckley; Marshall E Kadin; Carl R Kjeldsberg; Anna Meadows; Stuart Siegel; Jonathan Finlay; Sharon Bergeron; Mitchell S Cairo Journal: J Pediatr Hematol Oncol Date: 2004-03 Impact factor: 1.289
Authors: Matija Snuderl; Olga K Kolman; Yi-Bin Chen; Jessie J Hsu; Adam M Ackerman; Paola Dal Cin; Judith A Ferry; Nancy Lee Harris; Robert P Hasserjian; Lawrence R Zukerberg; Jeremy S Abramson; Ephraim P Hochberg; Hang Lee; Alfred I Lee; Christiana E Toomey; Aliyah R Sohani Journal: Am J Surg Pathol Date: 2010-03 Impact factor: 6.394
Authors: Itziar Salaverria; Idoia Martin-Guerrero; Rabea Wagener; Markus Kreuz; Christian W Kohler; Julia Richter; Barbara Pienkowska-Grela; Patrick Adam; Birgit Burkhardt; Alexander Claviez; Christine Damm-Welk; Hans G Drexler; Michael Hummel; Elaine S Jaffe; Ralf Küppers; Christine Lefebvre; Jasmin Lisfeld; Markus Löffler; Roderick A F Macleod; Inga Nagel; Ilske Oschlies; Maciej Rosolowski; Robert B Russell; Grzegorz Rymkiewicz; Detlev Schindler; Matthias Schlesner; René Scholtysik; Carsten Schwaenen; Rainer Spang; Monika Szczepanowski; Lorenz Trümper; Inga Vater; Swen Wessendorf; Wolfram Klapper; Reiner Siebert Journal: Blood Date: 2014-01-07 Impact factor: 22.113
Authors: Sietse M Aukema; Markus Kreuz; Christian W Kohler; Maciej Rosolowski; Dirk Hasenclever; Michael Hummel; Ralf Küppers; Dido Lenze; German Ott; Christiane Pott; Julia Richter; Andreas Rosenwald; Monika Szczepanowski; Carsten Schwaenen; Harald Stein; Heiko Trautmann; Swen Wessendorf; Lorenz Trümper; Markus Loeffler; Rainer Spang; Philip M Kluin; Wolfram Klapper; Reiner Siebert Journal: Haematologica Date: 2013-10-31 Impact factor: 9.941
Authors: Karen E Deffenbacher; Javeed Iqbal; Warren Sanger; Yulei Shen; Cynthia Lachel; Zhongfeng Liu; Yanyan Liu; Megan S Lim; Sherrie L Perkins; Kai Fu; Lynette Smith; James Lynch; Louis M Staudt; Lisa M Rimsza; Elaine Jaffe; Andreas Rosenwald; German K Ott; Jan Delabie; Elias Campo; Randy D Gascoyne; Mitchell S Cairo; Dennis D Weisenburger; Timothy C Greiner; Thomas G Gross; Wing C Chan Journal: Blood Date: 2012-02-28 Impact factor: 22.113
Authors: Alyssa Bouska; Chengfeng Bi; Waseem Lone; Weiwei Zhang; Ambreen Kedwaii; Tayla Heavican; Cynthia M Lachel; Jiayu Yu; Roberto Ferro; Nanees Eldorghamy; Timothy C Greiner; Julie Vose; Dennis D Weisenburger; Randy D Gascoyne; Andreas Rosenwald; German Ott; Elias Campo; Lisa M Rimsza; Elaine S Jaffe; Rita M Braziel; Reiner Siebert; Rodney R Miles; Sandeep Dave; Anupama Reddy; Jan Delabie; Louis M Staudt; Joo Y Song; Timothy W McKeithan; Kai Fu; Michael Green; Wing C Chan; Javeed Iqbal Journal: Blood Date: 2017-08-11 Impact factor: 22.113
Authors: Joshua D Schiffman; Patrick D Lorimer; Vladimir Rodic; Mona S Jahromi; Jonathan M Downie; Michael G Bayerl; Jennifer N Sanmann; Pamela A Althof; Warren G Sanger; Phillip Barnette; Sherrie L Perkins; Rodney R Miles Journal: Br J Haematol Date: 2011-10-08 Impact factor: 6.998
Authors: Mariana Tavares de Souza; Hasmik Mkrtchyan; Rocio Hassan; Daniela Ribeiro Ney-Garcia; Alice Maria Boulhosa de Azevedo; Elaine Sobral da Costa; Amanda Faria de Figueiredo; Thomas Liehr; Eliana Abdelhay; Maria Luiza Macedo Silva Journal: Int J Hematol Date: 2011-01-05 Impact factor: 2.490
Authors: Leticia Quintanilla-Martinez; Daphne de Jong; Antoine de Mascarel; Eric D Hsi; Philip Kluin; Yaso Natkunam; Marie Parrens; Stefano Pileri; German Ott Journal: J Hematop Date: 2009-12-22 Impact factor: 0.196