Literature DB >> 18697992

An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.

Justin L Grobe1, Di Xu, Curt D Sigmund.   

Abstract

The renin-angiotensin system in the brain acts to regulate a number of physiological processes. Evidence suggests that angiotensin peptides may act as neurotransmitters, although their biosynthetic pathways are poorly understood. We review evidence for neuronal production of angiotensin peptides and hypothesize that angiotensin may be synthesized intracellularly in neurons.

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Year:  2008        PMID： 18697992      PMCID： PMC2538674          DOI： 10.1152/physiol.00002.2008

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  52 in total

1.  Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model.

Authors:  Julie L Lavoie; Martin D Cassell; Kenneth W Gross; Curt D Sigmund
Journal:  Physiol Genomics       Date:  2004-01-15       Impact factor: 3.107

2.  Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice.

Authors:  Eric Lazartigues; Shannon M Dunlay; Angela K Loihl; Puspha Sinnayah; Julie A Lang; Joshua J Espelund; Curt D Sigmund; Robin L Davisson
Journal:  Circ Res       Date:  2002-03-22       Impact factor: 17.367

3.  Evidence for the existence of angiotensinogen mRNA in magnocellular paraventricular hypothalamic neurons.

Authors:  M Aronsson; K Almasan; K Fuxe; A Cintra; A Härfstrand; J A Gustafsson; D Ganten
Journal:  Acta Physiol Scand       Date:  1988-04

4.  Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.

Authors:  M Schinke; O Baltatu; M Böhm; J Peters; W Rascher; G Bricca; A Lippoldt; D Ganten; M Bader
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

5.  Angiotensin II immunoreactive pathways in the central nervous system of the rat: evidence for a projection from the subfornical organ to the paraventricular nucleus of the hypothalamus.

Authors:  R W Lind; L W Swanson; D Ganten
Journal:  Clin Exp Hypertens A       Date:  1984

6.  Angiotensinogen is secreted by pure rat neuronal cell cultures.

Authors:  W G Thomas; K J Greenland; T A Shinkel; C Sernia
Journal:  Brain Res       Date:  1992-08-21       Impact factor: 3.252

7.  Astrocytes synthesize angiotensinogen in brain.

Authors:  R L Stornetta; C L Hawelu-Johnson; P G Guyenet; K R Lynch
Journal:  Science       Date:  1988-12-09       Impact factor: 47.728

8.  In vivo activity of purified mouse brain renin.

Authors:  G Speck; K Poulsen; T Unger; R Rettig; C Bayer; B Schölkens; D Ganten
Journal:  Brain Res       Date:  1981-08-31       Impact factor: 3.252

9.  Characterization of a functional (pro)renin receptor in rat brain neurons.

Authors:  Zhiying Shan; Adolfo E Cuadra; Colin Sumners; Mohan K Raizada
Journal:  Exp Physiol       Date:  2008-03-07       Impact factor: 2.969

10.  Immunocytochemical localization of angiotensinogen in the rat brain.

Authors:  W G Thomas; C Sernia
Journal:  Neuroscience       Date:  1988-04       Impact factor: 3.590
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  82 in total

1.  Functional intracellular renin-angiotensin systems: potential for pathophysiology of disease.

Authors:  Robert M Carey
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-12-14       Impact factor: 3.619

2.  Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.

Authors:  Di Xu; Giulianna R Borges; Deborah R Davis; Khristofor Agassandian; Maria Luisa S Sequeira Lopez; R Ariel Gomez; Martin D Cassell; Justin L Grobe; Curt D Sigmund
Journal:  Physiol Genomics       Date:  2010-12-28       Impact factor: 3.107

3.  The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.

Authors:  Justin L Grobe; Connie L Grobe; Terry G Beltz; Scott G Westphal; Donald A Morgan; Di Xu; Willem J de Lange; Huiping Li; Koji Sakai; Daniel R Thedens; Lisa A Cassis; Kamal Rahmouni; Allyn L Mark; Alan Kim Johnson; Curt D Sigmund
Journal:  Cell Metab       Date:  2010-11-03       Impact factor: 27.287

4.  A map and new directions for the (pro)renin receptor in the brain: focus on "A role of the (pro)renin receptor in neuronal cell differentiation".

Authors:  Eric Lazartigues
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-06-03       Impact factor: 3.619

5.  High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.

Authors:  Silke Timmermans; Jeroen F J Bogie; Tim Vanmierlo; Dieter Lütjohann; Piet Stinissen; Niels Hellings; Jerome J A Hendriks
Journal:  J Neuroimmune Pharmacol       Date:  2013-09-26       Impact factor: 4.147

6.  Direct evidence of intracrine angiotensin II signaling in neurons.

Authors:  Elena Deliu; G Cristina Brailoiu; Satoru Eguchi; Nicholas E Hoffman; Joseph E Rabinowitz; Douglas G Tilley; Muniswamy Madesh; Walter J Koch; Eugen Brailoiu
Journal:  Am J Physiol Cell Physiol       Date:  2014-01-08       Impact factor: 4.249

7.  Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension.

Authors:  Keisuke Shinohara; Xuebo Liu; Donald A Morgan; Deborah R Davis; Maria Luisa S Sequeira-Lopez; Martin D Cassell; Justin L Grobe; Kamal Rahmouni; Curt D Sigmund
Journal:  Hypertension       Date:  2016-10-17       Impact factor: 10.190

Review 8.  Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

Authors:  Annette D de Kloet; Eric G Krause; Peng D Shi; Jasenka Zubcevic; Mohan K Raizada; Colin Sumners
Journal:  Pharmacol Ther       Date:  2013-02-28       Impact factor: 12.310

9.  Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent.

Authors:  Nicole K Littlejohn; Rick B Siel; Pimonrat Ketsawatsomkron; Christopher J Pelham; Nicole A Pearson; Aline M Hilzendeger; Beth A Buehrer; Benjamin J Weidemann; Huiping Li; Deborah R Davis; Anthony P Thompson; Xuebo Liu; Martin D Cassell; Curt D Sigmund; Justin L Grobe
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-03-27       Impact factor: 3.619

Review 10.  Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension.

Authors:  Nicole K Littlejohn; Justin L Grobe
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-10-21       Impact factor: 3.619
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