Literature DB >> 18697969

Mycophenolate mofetil: emerging as a potential human teratogen.

Gideon Koren.   

Abstract

ABSTRACTQUESTION One of my female patients conceived 2 years after renal transplant while using mycophenolate mofetil. She only realized she was pregnant at 14 weeks of gestation. How should I advise her?ANSWER Several recent case series show increased malformation rates with mycophenolate mofetil. Specifically, the repeated occurrence of phenotypic presentations of ear malformations, cleft lip and palate, and other malformations suggest that this is not by chance alone.

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Year:  2008        PMID： 18697969      PMCID： PMC2515265     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  9 in total

Review 1.  Pregnancy after organ transplant.

Authors:  Joan M Mastrobattista; Allan R Katz
Journal:  Obstet Gynecol Clin North Am       Date:  2004-06       Impact factor: 2.844

2.  Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus.

Authors:  Nicole M Sifontis; Lisa A Coscia; Serban Constantinescu; Antonella F Lavelanet; Michael J Moritz; Vincent T Armenti
Journal:  Transplantation       Date:  2006-12-27       Impact factor: 4.939

3.  Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis.

Authors:  B Bar Oz; R Hackman; T Einarson; G Koren
Journal:  Transplantation       Date:  2001-04-27       Impact factor: 4.939

Review 4.  In utero exposure to immunosuppressive drugs: experimental and clinical studies.

Authors:  Anais Tendron; J-B Gouyon; S Decramer
Journal:  Pediatr Nephrol       Date:  2002-02       Impact factor: 3.714

Review 5.  Kidney transplantation during the first trimester of pregnancy: immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone.

Authors:  P E Pérgola; A Kancharla; D J Riley
Journal:  Transplantation       Date:  2001-04-15       Impact factor: 4.939

6.  Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.

Authors:  H W Sollinger
Journal:  Transplantation       Date:  1995-08-15       Impact factor: 4.939

7.  In utero exposure to mycophenolate mofetil: a characteristic phenotype?

Authors:  Antonio Perez-Aytes; Ana Ledo; Virginia Boso; Pilar Sáenz; Eva Roma; José Luis Poveda; Maximo Vento
Journal:  Am J Med Genet A       Date:  2008-01-01       Impact factor: 2.802

8.  Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations.

Authors:  Camille Le Ray; Aurore Coulomb; Elisabeth Elefant; Rene Frydman; François Audibert
Journal:  Obstet Gynecol       Date:  2004-05       Impact factor: 7.661

Review 9.  Immunosuppression in pregnancy: choices for infant and maternal health.

Authors:  Vincent T Armenti; Michael J Moritz; Elyce H Cardonick; John M Davison
Journal:  Drugs       Date:  2002       Impact factor: 9.546
  9 in total
  2 in total

1.  Kidney transplantation during a twin pregnancy. Case report and review of the literature.

Authors:  Jorge Vega; Christian Videla; Oscar Santis; Mauricio Lira; Helmuth Goecke
Journal:  CEN Case Rep       Date:  2012-04-11

2.  Myasthenia gravis during pregnancy.

Authors:  Shahnaz Akhtar Chaudhry; Biruthvie Vignarajah; Gideon Koren
Journal:  Can Fam Physician       Date:  2012-12       Impact factor: 3.275
  2 in total

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