Natwar Lal Sharma1, Venkataraman Vishwanthan. 1. Department of Pediatric Neurology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India. drnutties2000@yahoo.co.in
Abstract
OBJECTIVES: To assess the seizure and developmental outcome in children with West syndrome with respect to treatment lag. METHODS: Twenty-six children satisfying inclusion criteria of West syndrome i.e., infantile spasms, psychomotor retardation and abnormal EEG pattern were prospectively evaluated. Response to treatment was assessed based on seizure control, EEG, developmental assessment and parental observations. RESULTS: The time lag from onset of seizures to appropriate treatment was <1 month in 11 children; 1-6 months in 8 children; and >6 months in 7 children. Children with treatment lag <1 month fared better than those who had a large treatment lag (P<0.05). Children with good seizure control also showed better developmental improvement (P<0.05). CONCLUSION: Children with West syndrome have better seizure control and development, if the treatment is started within 1 month of onset of symptoms.
OBJECTIVES: To assess the seizure and developmental outcome in children with West syndrome with respect to treatment lag. METHODS: Twenty-six children satisfying inclusion criteria of West syndrome i.e., infantile spasms, psychomotor retardation and abnormal EEG pattern were prospectively evaluated. Response to treatment was assessed based on seizure control, EEG, developmental assessment and parental observations. RESULTS: The time lag from onset of seizures to appropriate treatment was <1 month in 11 children; 1-6 months in 8 children; and >6 months in 7 children. Children with treatment lag <1 month fared better than those who had a large treatment lag (P<0.05). Children with good seizure control also showed better developmental improvement (P<0.05). CONCLUSION:Children with West syndrome have better seizure control and development, if the treatment is started within 1 month of onset of symptoms.
Authors: James W Wheless; Patricia A Gibson; Kari Luther Rosbeck; Maria Hardin; Christine O'Dell; Vicky Whittemore; John M Pellock Journal: BMC Pediatr Date: 2012-07-25 Impact factor: 2.125