Literature DB >> 18694945

Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation.

Koichi Tanimoto1, Haruyoshi Tomita, Shuhei Fujimoto, Katsuko Okuzumi, Yasuyoshi Ike.   

Abstract

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

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Year:  2008        PMID： 18694945      PMCID： PMC2565900          DOI： 10.1128/AAC.00464-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Of Pseudomonas, porins, pumps and carbapenems.

Authors:  D M Livermore
Journal:  J Antimicrob Chemother       Date:  2001-03       Impact factor: 5.790

2.  In vitro antimicrobial activity of doripenem, a new carbapenem.

Authors:  Yigong Ge; Matthew A Wikler; Daniel F Sahm; Renée S Blosser-Middleton; James A Karlowsky
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

3.  Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections.

Authors:  J P Quinn; E J Dudek; C A DiVincenzo; D A Lucks; S A Lerner
Journal:  J Infect Dis       Date:  1986-08       Impact factor: 5.226

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein.

Authors:  K H Büscher; W Cullmann; W Dick; W Opferkuch
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

6.  Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa.

Authors:  J Trias; J Dufresne; R C Levesque; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

7.  Pyrosequencing for rapid identification of carbapenem-hydrolysing OXA-type beta-lactamases in Acinetobacter baumannii.

Authors:  T Naas; L Poirel; P Nordmann
Journal:  Clin Microbiol Infect       Date:  2006-12       Impact factor: 8.067

8.  Properties of the penicillin-binding proteins of Escherichia coli K12,.

Authors:  B G Spratt
Journal:  Eur J Biochem       Date:  1977-01

9.  Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia. A randomized, double-blind, placebo-controlled trial.

Authors:  J E Karp; W G Merz; C Hendricksen; B Laughon; T Redden; B J Bamberger; J G Bartlett; R Saral; P J Burke
Journal:  Ann Intern Med       Date:  1987-01       Impact factor: 25.391

10.  Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential.

Authors:  Shazad Mushtaq; Yigong Ge; David M Livermore
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191
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  17 in total

1.  Mutational Consequences of Ciprofloxacin in Escherichia coli.

Authors:  Lisa Yun Song; Marisa Goff; Christina Davidian; Zhiyuan Mao; Marisa London; Karen Lam; Madeline Yung; Jeffrey H Miller
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Clinical efficacy of intravenous doripenem in patients with acute biliary tract infection: a multicenter, randomized, controlled trial with imipenem/cilastatin as comparator.

Authors:  Susumu Tazuma; Yoshinori Igarashi; Kazuo Inui; Hirotaka Ohara; Toshio Tsuyuguchi; Shomei Ryozawa
Journal:  J Gastroenterol       Date:  2014-05-03       Impact factor: 7.527

Review 3.  Structure and function of OprD protein in Pseudomonas aeruginosa: from antibiotic resistance to novel therapies.

Authors:  Hui Li; Yi-Feng Luo; Bryan J Williams; Timothy S Blackwell; Can-Mao Xie
Journal:  Int J Med Microbiol       Date:  2012-01-05       Impact factor: 3.473

4.  Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates.

Authors:  Natalija Karabasevic; Jason A Roberts; Luke Stronach; Saiyuri Naicker; Steven C Wallis; Fredrik Sjövall; Fekade Sime
Journal:  Antimicrob Agents Chemother       Date:  2022-04-07       Impact factor: 5.938

5.  Identification of novel genes responsible for overexpression of ampC in Pseudomonas aeruginosa PAO1.

Authors:  Yuko Tsutsumi; Haruyoshi Tomita; Koichi Tanimoto
Journal:  Antimicrob Agents Chemother       Date:  2013-09-16       Impact factor: 5.191

Review 6.  The β-Lactams Strike Back: Ceftazidime-Avibactam.

Authors:  Evan J Zasowski; Jeffrey M Rybak; Michael J Rybak
Journal:  Pharmacotherapy       Date:  2015-08       Impact factor: 4.705

7.  Fluoroquinolone Prophylaxis Selects for Meropenem-nonsusceptible Pseudomonas aeruginosa in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.

Authors:  Morgan Hakki; Romney M Humphries; Peera Hemarajata; Gregory B Tallman; Ryan K Shields; Roberta T Mettus; Yohei Doi; James S Lewis
Journal:  Clin Infect Dis       Date:  2019-05-30       Impact factor: 9.079

Review 8.  Multidrug-resistant Gram-negative infections: what are the treatment options?

Authors:  Helen Giamarellou; Garyphallia Poulakou
Journal:  Drugs       Date:  2009-10-01       Impact factor: 9.546

9.  Changes in gram negative microorganisms' resistance pattern during 4 years period in a referral teaching hospital; a surveillance study.

Authors:  Hossein Khalili; Simin Dashti-Khavidaki; Mohammad-Reza Shahidi; Alireza Abdollahi; Sirous Jafari; Zahra Jahangard-Rafsanjani; Azita-Hajhosssein Talasaz
Journal:  Daru       Date:  2012-09-10       Impact factor: 3.117

10.  The multifaceted roles of antibiotics and antibiotic resistance in nature.

Authors:  Saswati Sengupta; Madhab K Chattopadhyay; Hans-Peter Grossart
Journal:  Front Microbiol       Date:  2013-03-12       Impact factor: 5.640
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