| Literature DB >> 18694756 |
Ivan Wawrzyniak1, Michaël Roussel, Marie Diogon, Arnaud Couloux, Catherine Texier, Kevin S W Tan, Christian P Vivarès, Frédéric Delbac, Patrick Wincker, Hicham El Alaoui.
Abstract
Blastocystis hominis is an anaerobic parasite of the human intestinal tract belonging to the Stramenopile group. Using genome sequencing project data, we describe here the complete sequence of a 29,270-bp circular DNA molecule that presents mitochondrial features (such as oxidative phosphorylation complex I subunits) but lacks complexes III, IV and V. Transmission electron microscopy analyses reveal that this molecule, as well as mitochondrial (NADH:ubiquinone oxidoreductase subunit 7 (NAD7), beta-succinyl-CoA synthetase (beta-SCS)) and hydrogenosomal (pyruvate ferredoxin oxido-reductase (PFOR), iron-hydrogenase) proteins, are located within double-membrane surrounded-compartments known as mitochondria-like organelles (MLOs). As there is no evidence for hydrogen production by this organism, we suggest that MLOs are more likely anaerobic mitochondria.Entities:
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Year: 2008 PMID： 18694756 DOI： 10.1016/j.ijpara.2008.06.001
Source DB: PubMed Journal: Int J Parasitol ISSN： 0020-7519 Impact factor: 3.981