Literature DB >> 18694641

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.

David A Scott1, Brian M Aquila, Geraldine A Bebernitz, Donald J Cook, Les A Dakin, Tracy L Deegan, Maureen M Hattersley, Stephanos Ioannidis, Paul D Lyne, Charles A Omer, Minwei Ye, Xiaolan Zheng.   

Abstract

The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.

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Year:  2008        PMID: 18694641     DOI: 10.1016/j.bmcl.2008.07.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  High expression of macrophage colony-stimulating factor-1 receptor in peritumoral liver tissue is associated with poor outcome in hepatocellular carcinoma after curative resection.

Authors:  Jin-Bin Jia; Wen-Quan Wang; Hui-Chuan Sun; Xiao-Dong Zhu; Liang Liu; Peng-Yuan Zhuang; Ju-Bo Zhang; Wei Zhang; Hua-Xiang Xu; Ling-Qun Kong; Lu Lu; Wei-Zhong Wu; Lu Wang; Zhao-You Tang
Journal:  Oncologist       Date:  2010-06-15

2.  CSF-1R regulates non-small cell lung cancer cells dissemination through Wnt3a signaling.

Authors:  Yan Xia Yu; Hai Jian Wu; Bing Xu Tan; Chen Qiu; Hui Zhong Liu
Journal:  Am J Cancer Res       Date:  2017-11-01       Impact factor: 6.166

  2 in total

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