AIM: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. MATERIALS & METHODS: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. RESULTS & DISCUSSION: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. CONCLUSIONS: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.
AIM: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. MATERIALS & METHODS:Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to humannonsmall cell lung cancer-cell NCI-H460-bearing mice. RESULTS & DISCUSSION: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. CONCLUSIONS: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.
Authors: Jianfei Zhang; Jiechao Ge; Michael D Shultz; Eunna Chung; Gurpreet Singh; Chunying Shu; Panos P Fatouros; Scott C Henderson; Frank D Corwin; David B Geohegan; Alex A Puretzky; Christopher M Rouleau; Karren More; Christopher Rylander; Marissa Nichole Rylander; Harry W Gibson; Harry C Dorn Journal: Nano Lett Date: 2010-08-11 Impact factor: 11.189
Authors: Brittany R Bitner; Daniela C Marcano; Jacob M Berlin; Roderic H Fabian; Leela Cherian; James C Culver; Mary E Dickinson; Claudia S Robertson; Robia G Pautler; Thomas A Kent; James M Tour Journal: ACS Nano Date: 2012-08-15 Impact factor: 15.881
Authors: Satish K Nune; Padmaja Gunda; Bharat K Majeti; Praveen K Thallapally; M Laird Forrest Journal: Adv Drug Deliv Rev Date: 2011-06-28 Impact factor: 17.873