BACKGROUND: Migraine occurs with a high prevalence of 18 per cent. Management requires a tailored regimen of pharmacological and other measures based on individual clinical history. In some patients, allergen-specific IgG has been suspected to be involved in their mechanism, however, serological methods to investigate such possibility, are seldomly used. OBJECTIVE: The aim of this study was to investigate allergen-specific IgG in serum of patients with migraine refractory to traditional treatment. MATERIAL AND METHODS: Serum antibodies to specific 108 food allergens were measured by enzyme immunoassay from 56 patients with migraine and a control group without migraine. RESULTS: In addition to statistical significant differences in the number of positives for IgG food allergens between patients with migraine and a controlled group, elimination diets successfully control the migraine without the need of medications. CONCLUSION: According to the results obtained, serum IgG antibodies to common food should be investigated in patients with migraine.
BACKGROUND:Migraine occurs with a high prevalence of 18 per cent. Management requires a tailored regimen of pharmacological and other measures based on individual clinical history. In some patients, allergen-specific IgG has been suspected to be involved in their mechanism, however, serological methods to investigate such possibility, are seldomly used. OBJECTIVE: The aim of this study was to investigate allergen-specific IgG in serum of patients with migraine refractory to traditional treatment. MATERIAL AND METHODS: Serum antibodies to specific 108 food allergens were measured by enzyme immunoassay from 56 patients with migraine and a control group without migraine. RESULTS: In addition to statistical significant differences in the number of positives for IgG food allergens between patients with migraine and a controlled group, elimination diets successfully control the migraine without the need of medications. CONCLUSION: According to the results obtained, serum IgG antibodies to common food should be investigated in patients with migraine.
Authors: Brette D Blakely; Christopher R Bye; Chathurini V Fernando; Malcolm K Horne; Maria L Macheda; Steven A Stacker; Ernest Arenas; Clare L Parish Journal: PLoS One Date: 2011-03-31 Impact factor: 3.240