Literature DB >> 18693100

A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity.

P Daisy1, R Jasmine, S Ignacimuthu, E Murugan.   

Abstract

Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.

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Year:  2008        PMID： 18693100     DOI： 10.1016/j.phymed.2008.06.001

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  9 in total

1.  In vitro α-amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus macroptera Montr. fruit.

Authors:  Nizam Uddin; Md Rakib Hasan; Md Monir Hossain; Arjyabrata Sarker; A H M Nazmul Hasan; A F M Mahmudul Islam; Mohd Motaher H Chowdhury; Md Sohel Rana
Journal:  Asian Pac J Trop Biomed       Date:  2014-06

2.  Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

Authors:  Debasis De; Kausik Chatterjee; Kazi Monjur Ali; Tushar Kanti Bera; Debidas Ghosh
Journal:  Evid Based Complement Alternat Med       Date:  2010-09-28       Impact factor: 2.629

3.  Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity.

Authors:  Vikas Kumar; Firoz Anwar; Danish Ahmed; Amita Verma; Aftab Ahmed; Zoheir A Damanhouri; Vatsala Mishra; Pramod W Ramteke; Prakash Chandra Bhatt; Mohd Mujeeb
Journal:  BMC Complement Altern Med       Date:  2014-02-25       Impact factor: 3.659

4.  Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells.

Authors:  Victor Kuete; Fabrice W Fokou; Oğuzhan Karaosmanoğlu; Veronique P Beng; Hülya Sivas
Journal:  BMC Complement Altern Med       Date:  2017-05-25       Impact factor: 3.659

5.  Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells.

Authors:  Chim-Kei Chan; Loh Teng-Hern Tan; Shathiswaran N Andy; Muhamad Noor Alfarizal Kamarudin; Bey-Hing Goh; Habsah Abdul Kadir
Journal:  Front Pharmacol       Date:  2017-06-21       Impact factor: 5.810

6.  Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activity.

Authors:  Narayanasamy Nivetha; Reshma Mary Martiz; Shashank M Patil; Ramith Ramu; Swamy Sreenivasa; Sivan Velmathi
Journal:  RSC Adv       Date:  2022-08-25       Impact factor: 4.036

7.  Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-α-D-glucopyranosyl-(2(I) → 1(II))-α-D-glucopyranoside in streptozotocin induced diabetic rats.

Authors:  Vikas Kumar; Danish Ahmed; Firoz Anwar; Mohammed Ali; Mohd Mujeeb
Journal:  Springerplus       Date:  2013-11-28

8.  Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats.

Authors:  Leila Moezi; Seyede Samira Arshadi; Tahere Motazedian; Seyed Hassan Seradj; Farzaneh Dehghani
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696

9.  Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal.

Authors:  Kusum Sai; Sumit Bahadur Baruwal Chhetri; Shankar Raj Devkota; Deepa Khatri
Journal:  ScientificWorldJournal       Date:  2021-06-25
  9 in total

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