Literature DB >> 18692208

[Candida albicans cerebral granuloma in an immunocompetent patient. A case report].

A Borha1, J-J Parienti, E Emery, O Coskun, S Khouri, J-M Derlon.   

Abstract

We report a case of temporal lobe granuloma caused by Candida albicans in an immunocompetent patient. This 54-year-old patient had experienced headaches and some memory disorders for two to three months before his admission to the neurosurgical department. Cerebral-computer tomography and magnetic resonance imaging showed a single right-temporal lesion with a large peritumoral edema. We operated on the patient via a temporal approach using neuronavigation and resected the lesion. The anatomopathological result and the cultures of the granuloma showed C. albicans species. The patient received antifungal therapy for three months. No predisposing factors or immunosuppression was found. After seven months, he presented an ischemic cerebrovascular accident of the brain stem and then chronic meningitis complicated by hydrocephalus. The patient's condition progressively deteriorated and he died 18 months later in an other department. C. albicans can be found even in the immunocompetent patient, but is seldom observed. Surgery can provide an accurate diagnosis and therapeutic management in the initial phase, completed by antifungal therapy.

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Year:  2008        PMID: 18692208     DOI: 10.1016/j.neuchi.2008.06.001

Source DB:  PubMed          Journal:  Neurochirurgie        ISSN: 0028-3770            Impact factor:   1.553


  6 in total

1.  Imaging Candida Infections in the Host.

Authors:  Dhammika H Navarathna; David D Roberts; Jeeva Munasinghe; Martin J Lizak
Journal:  Methods Mol Biol       Date:  2016

2.  Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both.

Authors:  Fanny Lanternier; Seyed Alireza Mahdaviani; Elisa Barbati; Hélène Chaussade; Yatrika Koumar; Romain Levy; Blandine Denis; Anne-Sophie Brunel; Sophie Martin; Michèle Loop; Julie Peeters; Ariel de Selys; Jean Vanclaire; Christiane Vermylen; Marie-Cécile Nassogne; Olga Chatzis; Luyan Liu; Mélanie Migaud; Vincent Pedergnana; Guillaume Desoubeaux; Gregory Jouvion; Fabrice Chretien; Ilad Alavi Darazam; Alejandro A Schäffer; Mihai G Netea; Jean J De Bruycker; Louis Bernard; Jacques Reynes; Noureddine Amazrine; Laurent Abel; Dimitri Van der Linden; Tom Harrison; Capucine Picard; Olivier Lortholary; Davood Mansouri; Jean-Laurent Casanova; Anne Puel
Journal:  J Allergy Clin Immunol       Date:  2015-02-19       Impact factor: 10.793

3.  MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.

Authors:  Dhammika H M L P Navarathna; Jeeva Munasinghe; Martin J Lizak; Debasis Nayak; Dorian B McGavern; David D Roberts
Journal:  NMR Biomed       Date:  2013-04-22       Impact factor: 4.044

4.  Experimental autoimmune encephalomyelitis development is aggravated by Candida albicans infection.

Authors:  Thais F C Fraga-Silva; Luiza A N Mimura; Camila M Marchetti; Fernanda Chiuso-Minicucci; Thais G D França; Sofia F G Zorzella-Pezavento; James Venturini; Maria S P Arruda; Alexandrina Sartori
Journal:  J Immunol Res       Date:  2015-04-19       Impact factor: 4.818

Review 5.  Fungal Infection in the Brain: What We Learned from Intravital Imaging.

Authors:  Meiqing Shi; Christopher H Mody
Journal:  Front Immunol       Date:  2016-08-02       Impact factor: 7.561

Review 6.  CSF in acute and chronic infectious diseases.

Authors:  Felix Benninger; Israel Steiner
Journal:  Handb Clin Neurol       Date:  2017
  6 in total

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