Literature DB >> 18691924

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

Ryuji Yamaguchi1, Lydia Lartigue1, Guy Perkins2, Ray T Scott2, Amruta Dixit2, Yulia Kushnareva1, Tomomi Kuwana3, Mark H Ellisman2, Donald D Newmeyer4.   

Abstract

Controversy surrounds the role and mechanism of mitochondrial cristae remodeling in apoptosis. Here we show that the proapoptotic BH3-only proteins Bid and Bim induced full cytochrome c release but only a subtle alteration of crista junctions, which involved the disassembly of Opa1 complexes. Both mitochondrial outer membrane permeabilization (MOMP) and crista junction opening (CJO) were caspase independent and required a functional BH3 domain and Bax/Bak. However, MOMP and CJO were experimentally separable. Pharmacological blockade of MOMP did not prevent Opa1 disassembly and CJO; moreover, expression of a disassembly-resistant mutant Opa1 (Q297V) blocked cytochrome c release and apoptosis but not Bax activation. Thus, apoptosis requires a subtle form of Opa1-dependent crista remodeling that is induced by BH3-only proteins and Bax/Bak but independent of MOMP.

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Year:  2008        PMID： 18691924      PMCID： PMC2636708          DOI： 10.1016/j.molcel.2008.07.010

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  31 in total

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Authors:  E Bossy-Wetzel; D D Newmeyer; D R Green
Journal:  EMBO J       Date:  1998-01-02       Impact factor: 11.598

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Authors:  Tomomi Kuwana; Mason R Mackey; Guy Perkins; Mark H Ellisman; Martin Latterich; Roger Schneiter; Douglas R Green; Donald D Newmeyer
Journal:  Cell       Date:  2002-11-01       Impact factor: 41.582

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  115 in total

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Review 6.  Apoptotic cell death regulation in neurons.

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7.  Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements.

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10.  Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.

Authors:  Christi T Salisbury-Ruf; Clinton C Bertram; Aurelia Vergeade; Daniel S Lark; Qiong Shi; Marlene L Heberling; Niki L Fortune; G Donald Okoye; W Gray Jerome; Quinn S Wells; Josh Fessel; Javid Moslehi; Heidi Chen; L Jackson Roberts; Olivier Boutaud; Eric R Gamazon; Sandra S Zinkel
Journal:  Elife       Date:  2018-10-03       Impact factor: 8.140
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