| Literature DB >> 18691727 |
Feras Q Alali1, Yahya R Tahboub, Eyad S Ibrahim, Amjad M Qandil, Khaled Tawaha, Jason P Burgess, Arlene Sy, Yuka Nakanishi, David J Kroll, Nicholas H Oberlies.
Abstract
The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml).Entities:
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Year: 2008 PMID： 18691727 DOI： 10.1016/j.phytochem.2008.06.017
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072