AIMS OF STUDY: Although Asparagus cochinchinensis Merrill (Liliaceae) has long been used in traditional Korean and Chinese medicine to treat inflammatory diseases, the underlying mechanism(s) by which these effects are induced remains to be defined. We investigated the effects of 70% ethanolic extract from Asparagus cochinchinensis Merrill (ACE) on skin inflammation in mice. MATERIALS AND METHODS: Production of pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta), activation of myeloperoxidase, and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema. We also performed acetic acid-induced vascular permeability test. RESULTS: ACE inhibited topical edema in the mouse ear, following administration at 200mg/kg (i.p.), leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase (MPO) activity, and various histopathological indicators. Furthermore, ACE was effective at reducing inflammatory damage induced by chronic TPA exposure and evoked a significant inhibition of vascular permeability induced by acetic acid in mice. CONCLUSION: These results demonstrate that ACE is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis, and suggest that the compound may have therapeutic potential in a variety of immune-related cutaneous diseases.
AIMS OF STUDY: Although Asparagus cochinchinensis Merrill (Liliaceae) has long been used in traditional Korean and Chinese medicine to treat inflammatory diseases, the underlying mechanism(s) by which these effects are induced remains to be defined. We investigated the effects of 70% ethanolic extract from Asparagus cochinchinensis Merrill (ACE) on skin inflammation in mice. MATERIALS AND METHODS: Production of pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta), activation of myeloperoxidase, and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema. We also performed acetic acid-induced vascular permeability test. RESULTS:ACE inhibited topical edema in the mouse ear, following administration at 200mg/kg (i.p.), leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase (MPO) activity, and various histopathological indicators. Furthermore, ACE was effective at reducing inflammatory damage induced by chronic TPA exposure and evoked a significant inhibition of vascular permeability induced by acetic acid in mice. CONCLUSION: These results demonstrate that ACE is an effective anti-inflammatory agent in murinephorbol ester-induced dermatitis, and suggest that the compound may have therapeutic potential in a variety of immune-related cutaneous diseases.
Authors: Ju Hee Lee; Hun Jai Lim; Chan Woo Lee; Kun-Ho Son; Jong-Keun Son; Sang Kook Lee; Hyun Pyo Kim Journal: Evid Based Complement Alternat Med Date: 2015-08-25 Impact factor: 2.629
Authors: Hyun Ah Lee; Bo Ram Song; Hye Ryeong Kim; Ji Eun Kim; Woo Bin Yun; Jin Ju Park; Mi Lim Lee; Jun Young Choi; Hee Seob Lee; Dae Youn Hwang Journal: Exp Ther Med Date: 2017-09-25 Impact factor: 2.447
Authors: Padmalatha S Rai; Ravishankara Bellampalli; Rajendra M Dobriyal; Amit Agarwal; K Satyamoorthy; Db Anantha Narayana Journal: J Ayurveda Integr Med Date: 2012-07
Authors: Juarana Dal Mas; Tailyn Zermiani; Liliani C Thiesen; Joana Lm Silveira; Kathryn Abs da Silva; Márcia M de Souza; Angela Malheiros; Tania Mb Bresolin; Ruth M Lucinda-Silva Journal: Int J Nanomedicine Date: 2016-09-06