| Literature DB >> 18689980 |
Hyun Soon Lee1, Chi Young Song.
Abstract
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright 2008 S. Karger AG, Basel.Entities:
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Year: 2008 PMID: 18689980 DOI: 10.1159/000151277
Source DB: PubMed Journal: Am J Nephrol ISSN: 0250-8095 Impact factor: 3.754