Chen-Liang Lin1, Chinson Yeh1, Chen-Wen Yen2, Wu-Huei Hsu3, Liang-Wen Hang4. 1. Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Kaohsiung. 2. Sleep Medicine Center, Taichung, Taiwan. 3. Department of Internal Medicine, and Division of Pulmonary and Critical Care, Taichung, Taiwan. 4. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: lungwen.hang@gmail.com.
Abstract
OBJECTIVES: To comprehensively evaluate the ability and reliability of the representative previously proposed oxyhemoglobin indexes derived automatically for predicting the severity of obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Patients with a diagnosis of OSAHS by standard polysomnography were recruited from China Medical University Hospital Centre. There were 257 patients in the learning set and 279 patients in the validation set. The presence of OSAHS was defined as apnea-hypopnea index (AHI) > 5/h. Three kinds of oxyhemoglobin indexes, including the oxyhemoglobin desaturation index (ODI), time-domain index, and frequency-domain index, were used. Degrees of severity were AHI > 15/h and AHI > 30/h, representing moderate and severe OSAHS. A total of 28 oxyhemoglobin indexes were tested in our study. RESULTS: Among the three kinds of indexes, ODI had a better diagnostic performance than the time-domain and frequency-domain indexes, with the results coincident in the validation set and learning set. For predicting the severity of OSAHS with AHI > 15/h or > 30/h, the ODI clinically had the higher correlation with AHI than time-domain and frequency-domain indexes, with sensitivity/specificity achieving 84.0%/84.3% in AHI > 15/h and 87.8%/96.6% in AHI > 30/h, respectively. CONCLUSIONS: Based on the smaller SEE of the AHI, the ODI had a significantly smaller SEE than the time-domain and frequency-domain indexes. The ODI index provided a high level of diagnostic sensitivity and specificity at different degrees of OSAHS severity.
OBJECTIVES: To comprehensively evaluate the ability and reliability of the representative previously proposed oxyhemoglobin indexes derived automatically for predicting the severity of obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS:Patients with a diagnosis of OSAHS by standard polysomnography were recruited from China Medical University Hospital Centre. There were 257 patients in the learning set and 279 patients in the validation set. The presence of OSAHS was defined as apnea-hypopnea index (AHI) > 5/h. Three kinds of oxyhemoglobin indexes, including the oxyhemoglobin desaturation index (ODI), time-domain index, and frequency-domain index, were used. Degrees of severity were AHI > 15/h and AHI > 30/h, representing moderate and severe OSAHS. A total of 28 oxyhemoglobin indexes were tested in our study. RESULTS: Among the three kinds of indexes, ODI had a better diagnostic performance than the time-domain and frequency-domain indexes, with the results coincident in the validation set and learning set. For predicting the severity of OSAHS with AHI > 15/h or > 30/h, the ODI clinically had the higher correlation with AHI than time-domain and frequency-domain indexes, with sensitivity/specificity achieving 84.0%/84.3% in AHI > 15/h and 87.8%/96.6% in AHI > 30/h, respectively. CONCLUSIONS: Based on the smaller SEE of the AHI, the ODI had a significantly smaller SEE than the time-domain and frequency-domain indexes. The ODI index provided a high level of diagnostic sensitivity and specificity at different degrees of OSAHS severity.
Authors: Brandon T Nokes; Hassan A Raza; Rodrigo Cartin-Ceba; Phillip J Lyng; Lois E Krahn; Lewis Wesselius; Clinton E Jokerst; Sarah B Umar; W Leroy Griffing; Matthew R Neville; Atul Malhotra; James M Parish Journal: J Clin Sleep Med Date: 2019-11-15 Impact factor: 4.062
Authors: Nasser D Alqahtani; Mohamed I Algowaifly; Fahad A Almehizia; Zeyad A Alraddadi; Fares S Al-Sehaibany; Naif A Almosa; Sahar F Albarakati; Ahmed S Bahammam Journal: Saudi Med J Date: 2018-09 Impact factor: 1.484