Literature DB >> 18689486

Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa.

Michael F Clarke-Pearson1, Sean F Brady.   

Abstract

The pvc gene cluster from Pseudomonas aeruginosa has been linked to the biosynthesis of both the pyoverdine chromophore and pseudoverdine. Our reinvestigation of the role this gene cluster plays in P. aeruginosa secondary metabolite biosynthesis shows that its major product is actually paerucumarin, a novel isonitrile functionalized cumarin.

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Year:  2008        PMID： 18689486      PMCID： PMC2566218          DOI： 10.1128/JB.00801-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

1.  Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.

Authors:  L Xun; E R Sandvik
Journal:  Appl Environ Microbiol       Date:  2000-02       Impact factor: 4.792

2.  Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.

Authors:  Sean F Brady; John D Bauer; Michael F Clarke-Pearson; Rachel Daniels
Journal:  J Am Chem Soc       Date:  2007-09-19       Impact factor: 15.419

Review 3.  Molecular biology of the LysR family of transcriptional regulators.

Authors:  M A Schell
Journal:  Annu Rev Microbiol       Date:  1993       Impact factor: 15.500

4.  Genomics of pyoverdine-mediated iron uptake in pseudomonads.

Authors:  Jacques Ravel; Pierre Cornelis
Journal:  Trends Microbiol       Date:  2003-05       Impact factor: 17.079

5.  Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector.

Authors:  J P Fürste; W Pansegrau; R Frank; H Blöcker; P Scholz; M Bagdasarian; E Lanka
Journal:  Gene       Date:  1986       Impact factor: 3.688

6.  Identification of pilR, which encodes a transcriptional activator of the Pseudomonas aeruginosa pilin gene.

Authors:  K S Ishimoto; S Lory
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

7.  A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.

Authors:  T T Hoang; R R Karkhoff-Schweizer; A J Kutchma; H P Schweizer
Journal:  Gene       Date:  1998-05-28       Impact factor: 3.688

8.  Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.

Authors:  Jane A Colmer-Hamood; Hironori Aramaki; Jennifer M Gaines; Abdul N Hamood
Journal:  Can J Microbiol       Date:  2006-04       Impact factor: 3.226

9.  Regulation of Pseudomonas aeruginosa ptxR by Vfr.

Authors:  Evan Ferrell; Nancy L Carty; Jane A Colmer-Hamood; Abdul N Hamood; Susan E H West
Journal:  Microbiology (Reading)       Date:  2008-02       Impact factor: 2.956

10.  Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production.

Authors:  A N Hamood; J A Colmer; U A Ochsner; M L Vasil
Journal:  Mol Microbiol       Date:  1996-07       Impact factor: 3.979
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  20 in total

1.  Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.

Authors:  Nicholas C Harris; Michio Sato; Nicolaus A Herman; Frederick Twigg; Wenlong Cai; Joyce Liu; Xuejun Zhu; Jordan Downey; Ryan Khalaf; Joelle Martin; Hiroyuki Koshino; Wenjun Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-20       Impact factor: 11.205

Review 2.  Signaling Natural Products from Human Pathogenic Bacteria.

Authors:  Zhijuan Hu; Wenjun Zhang
Journal:  ACS Infect Dis       Date:  2019-10-30       Impact factor: 5.084

3.  Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases.

Authors:  Tzu-Yu Chen; Jinfeng Chen; Yijie Tang; Jiahai Zhou; Yisong Guo; Wei-Chen Chang
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-10       Impact factor: 15.336

4.  The Pseudomonas aeruginosa extracellular secondary metabolite, Paerucumarin, chelates iron and is not localized to extracellular membrane vesicles.

Authors:  Uzma Qaisar; Cassandra J Kruczek; Muhammed Azeem; Nasir Javaid; Jane A Colmer-Hamood; Abdul N Hamood
Journal:  J Microbiol       Date:  2016-08-02       Impact factor: 3.422

5.  Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity.

Authors:  Nicholas Raffa; Tae Hyung Won; Andrew Sukowaty; Kathleen Candor; Chengsen Cui; Saayak Halder; Mingji Dai; Julio A Landero-Figueroa; Frank C Schroeder; Nancy P Keller
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-23       Impact factor: 11.205

6.  Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Authors:  Antonio Del Rio Flores; David W Kastner; Yongle Du; Maanasa Narayanamoorthy; Yuanbo Shen; Wenlong Cai; Vyshnavi Vennelakanti; Nicholas A Zill; Luisa B Dell; Rui Zhai; Heather J Kulik; Wenjun Zhang
Journal:  J Am Chem Soc       Date:  2022-03-07       Impact factor: 15.419

7.  Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Authors:  Nicholas C Harris; David A Born; Wenlong Cai; Yaobing Huang; Joelle Martin; Ryan Khalaf; Catherine L Drennan; Wenjun Zhang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-03       Impact factor: 15.336

8.  Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

Authors:  Eric J Drake; Andrew M Gulick
Journal:  J Mol Biol       Date:  2008-09-19       Impact factor: 5.469

9.  The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection.

Authors:  Jelly Vanderwoude; Derek Fleming; Sheyda Azimi; Urvish Trivedi; Kendra P Rumbaugh; Stephen P Diggle
Journal:  Proc Biol Sci       Date:  2020-10-21       Impact factor: 5.349

10.  Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa.

Authors:  Justyna W Adamiak; Varsha Jhawar; Vincent Bonifay; Courtney E Chandler; Inga V Leus; Robert K Ernst; Herbert P Schweizer; Helen I Zgurskaya
Journal:  Antimicrob Agents Chemother       Date:  2021-07-12       Impact factor: 5.191
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