Literature DB >> 18688491

Gemmacin B: bringing diversity back into focus.

Anna Robinson1, Gemma L Thomas, Richard J Spandl, Martin Welch, David R Spring.   

Abstract

Through the synthesis of a focused library and SAR investigations, a more potent analogue of gemmacin (discovered in a previous diversity-oriented synthesis (DOS) campaign), gemmacin B, was discovered.

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Year:  2008        PMID: 18688491     DOI: 10.1039/b809038f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  4 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

2.  Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity.

Authors:  Mélanie Uguen; Gemma Davison; Lukas J Sprenger; James H Hunter; Mathew P Martin; Shannon Turberville; Jessica E Watt; Bernard T Golding; Martin E M Noble; Hannah L Stewart; Michael J Waring
Journal:  J Med Chem       Date:  2022-08-09       Impact factor: 8.039

3.  Novel stereocontrolled syntheses of tashiromine and epitashiromine.

Authors:  Loránd Kiss; Enikő Forró; Ferenc Fülöp
Journal:  Beilstein J Org Chem       Date:  2015-04-30       Impact factor: 2.883

Review 4.  Antibiotics and bacterial resistance in the 21st century.

Authors:  Richard J Fair; Yitzhak Tor
Journal:  Perspect Medicin Chem       Date:  2014-08-28
  4 in total

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