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Literature DB >> 1868630

Resistance of the embryonic notochord to invasion by malignant neurogenic tumor cells in vitro.

Abstract

Very few tissues in vivo are resistant to invasion by malignant cells. In this paper, confrontation cultures consisting of chick embryonic notochord fragments and cell aggregates from three malignant neurogenic cell lines showed a resistance of the embryonic organ to malignant invasion by tumor cells. The mechanism of resistance remains unclear.

Entities: Disease Species

Mesh：

Substances：
Collagen

Year: 1991 PMID： 1868630 DOI： 10.1007/bf01769359

Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150

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References

28 in total

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Resistance of the embryonic notochord to invasion by malignant neurogenic tumor cells in vitro.

1. Adhesion of malignant and nonmalignant cells to cultured embryonic substrates.

2. Morphological studies on the resistance of cartilage to invasion by osteosarcoma cells in vitro and in vivo.

3. Growth of carcinomas in the region of the cartilage.

4. Effect of natural protease inhibitors and a chemoattractant on tumor cell invasion in vitro.

5. Inhibition of endothelial cell growth by a factor isolated from cartilage.

6. The resistance of certain tissues to invasion. II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme.

7. Interaction of malignant cells with salt-extracted cartilage in vitro.

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