Literature DB >> 18685777

Chemoenzymatic acylation of aminoglycoside antibiotics.

Nicholas M Llewellyn1, Jonathan B Spencer.   

Abstract

The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.

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Year:  2008        PMID： 18685777     DOI： 10.1039/b802248h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.

Authors:  Je Won Park; Sung Ryeol Park; Keshav Kumar Nepal; Ah Reum Han; Yeon Hee Ban; Young Ji Yoo; Eun Ji Kim; Eui Min Kim; Dooil Kim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Nat Chem Biol       Date:  2011-10-09       Impact factor: 15.040

Review 2.  Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Chem Soc Rev       Date:  2018-02-19       Impact factor: 54.564

Review 3.  Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.

Authors:  Kristin J Labby; Sylvie Garneau-Tsodikova
Journal:  Future Med Chem       Date:  2013-07       Impact factor: 3.808

Review 4.  Progress in aminocyclitol biosynthesis.

Authors:  Taifo Mahmud
Journal:  Curr Opin Chem Biol       Date:  2009-03-25       Impact factor: 8.822

5.  Highly selective acylation of polyamines and aminoglycosides by 5-acyl-5-phenyl-1,5-dihydro-4H-pyrazol-4-ones.

Authors:  Kostiantyn O Marichev; Estevan C Garcia; Kartick C Bhowmick; Daniel J Wherritt; Hadi Arman; Michael P Doyle
Journal:  Chem Sci       Date:  2017-08-30       Impact factor: 9.825

6.  KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity.

Authors:  Rajesh Rattinam; R Sidick Basha; Yung-Lin Wang; Zhe-Chong Wang; Ning-Shian Hsu; Kuan-Hung Lin; Saeid Malek Zadeh; Kamal Adhikari; Jin-Ping Lin; Tsung-Lin Li
Journal:  Biomedicines       Date:  2022-01-19

Review 7.  Biocatalyzed Synthesis of Glycostructures with Anti-infective Activity.

Authors:  Pilar Hoyos; Almudena Perona; Teodora Bavaro; Francesca Berini; Flavia Marinelli; Marco Terreni; María J Hernáiz
Journal:  Acc Chem Res       Date:  2022-08-09       Impact factor: 24.466

8.  Development of 6'-N-Acylated Isepamicin Analogs with Improved Antibacterial Activity Against Isepamicin-Resistant Pathogens.

Authors:  Yeon Hee Ban; Myoung Chong Song; Hee Jin Kim; Heejeong Lee; Jae Bok Wi; Je Won Park; Dong Gun Lee; Yeo Joon Yoon
Journal:  Biomolecules       Date:  2020-06-11

9.  Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.

Authors:  Yeon Hee Ban; Myoung Chong Song; Jae-Yeon Hwang; Hea-Lyung Shin; Hak Joong Kim; Seung Kon Hong; Na Joon Lee; Je Won Park; Sun-Shin Cha; Hung-Wen Liu; Yeo Joon Yoon
Journal:  Nat Chem Biol       Date:  2019-01-14       Impact factor: 15.040
  9 in total

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