PURPOSE OF REVIEW: To describe the most relevant recent findings concerning the molecular mechanisms involved in both fat and muscle tissues in cachectic cancer patients. RECENT FINDINGS: Relevant progress has been made in the mechanism of signalling protein metabolism in skeletal muscle. PI3K has a dual role inhibiting protein degradation by inhibition of Atrogin-1 and MuRF1 gene expression and facilitating AKT phosphorylation, leading to increased protein synthesis. Interestingly, Caspase-3 activity is intimately associated with myofibrillar protein degradation in muscle tissue. With respect to fat metabolism, increased lipolysis in human cancer cachexia seems to be directly connected to increased hormone-sensitive lipase activity. SUMMARY: The results and findings described in this review represent important progress in wasting disease mechanisms and may provide hints for future therapeutic approaches in cancer cachexia.
PURPOSE OF REVIEW: To describe the most relevant recent findings concerning the molecular mechanisms involved in both fat and muscle tissues in cachectic cancerpatients. RECENT FINDINGS: Relevant progress has been made in the mechanism of signalling protein metabolism in skeletal muscle. PI3K has a dual role inhibiting protein degradation by inhibition of Atrogin-1 and MuRF1 gene expression and facilitating AKT phosphorylation, leading to increased protein synthesis. Interestingly, Caspase-3 activity is intimately associated with myofibrillar protein degradation in muscle tissue. With respect to fat metabolism, increased lipolysis in humancancer cachexia seems to be directly connected to increased hormone-sensitive lipase activity. SUMMARY: The results and findings described in this review represent important progress in wasting disease mechanisms and may provide hints for future therapeutic approaches in cancer cachexia.
Authors: Jochen K Lennerz; Jonathan B Hurov; Lynn S White; Katherine T Lewandowski; Julie L Prior; G James Planer; Robert W Gereau; David Piwnica-Worms; Robert E Schmidt; Helen Piwnica-Worms Journal: Mol Cell Biol Date: 2010-08-23 Impact factor: 4.272
Authors: Mary G Rhoads; Susan C Kandarian; Fabio Pacelli; Giovan Battista Doglietto; Maurizio Bossola Journal: Eur J Cancer Date: 2010-01 Impact factor: 9.162
Authors: Josep M Argilés; Mireia Olivan; Sílvia Busquets; Francisco Javier López-Soriano Journal: Cancer Manag Res Date: 2010-01-22 Impact factor: 3.989