PURPOSE OF REVIEW: We review recent insights into the mechanisms and prevalence of accommodation. Accommodation refers to an acquired resistance of an organ graft to humoral injury and rejection. RECENT FINDINGS: Accommodation has been postulated to reflect changes in antibodies, control of complement and/or acquired resistance to injury by antibodies, complement or other factors. We discuss the importance of these mechanisms, highlighting new conclusions. SUMMARY: Accommodation may be a common, perhaps the most common, outcome of organ transplantation and, in some systems, a predictable outcome of organ xenotransplantation. Further understanding of how accommodation is induced and by what mechanisms it is manifest and maintained could have a profound impact on transplantation in general and perhaps on other fields.
PURPOSE OF REVIEW: We review recent insights into the mechanisms and prevalence of accommodation. Accommodation refers to an acquired resistance of an organ graft to humoral injury and rejection. RECENT FINDINGS: Accommodation has been postulated to reflect changes in antibodies, control of complement and/or acquired resistance to injury by antibodies, complement or other factors. We discuss the importance of these mechanisms, highlighting new conclusions. SUMMARY: Accommodation may be a common, perhaps the most common, outcome of organ transplantation and, in some systems, a predictable outcome of organ xenotransplantation. Further understanding of how accommodation is induced and by what mechanisms it is manifest and maintained could have a profound impact on transplantation in general and perhaps on other fields.
Authors: Alexandros Delikouras; Lynette D Fairbanks; Anne H Simmonds; Robert I Lechler; Anthony Dorling Journal: Eur J Immunol Date: 2003-11 Impact factor: 5.532
Authors: D K Cooper; P A Human; A G Rose; J Rees; M Keraan; B Reichart; E Du Toit; R Oriol Journal: J Thorac Cardiovasc Surg Date: 1989-03 Impact factor: 5.209