Roberto Anaya-Prado1, Juan A Delgado-Vázquez. 1. Department of Research and Education, Western Medical Center at Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico. robana@prodigy.net.mx
Abstract
PURPOSE OF REVIEW: To review the basic mechanisms involved during hypothermia and reperfusion, with special attention paid to efforts being made in refining solutions and the molecular characterization of cells during preservation. RECENT FINDINGS: Several graft-related molecules have been identified as correlating with early graft dysfunction and/or poor outcome in the immediate posttransplant period. Also, different inhibitors have been utilized to ameliorate the preservation-induced injury, alone or in combination with different preservation solutions. SUMMARY: Preservation-induced injury is a major contributing factor to early graft dysfunction in organ recipients. The success of organ transplantation is critically dependent on the quality of the donor organ. Donor-organ quality, in turn, is determined by a variety of factors, including donor age, donor management prior to organ procurement, the duration of hypothermic storage, and perfusion techniques utilized to protect organs from ischemia/reperfusion injury, which in turn cause a dramatic reprogramming of cell metabolism during organ transplantation. The expression of a number of inflammatory genes has been associated with early graft dysfunction and/or poor outcome in the immediate postoperative period. Some therapeutic manipulations have been demonstrated to be of significance in attaining near-normal organ function after transplantation.
PURPOSE OF REVIEW: To review the basic mechanisms involved during hypothermia and reperfusion, with special attention paid to efforts being made in refining solutions and the molecular characterization of cells during preservation. RECENT FINDINGS: Several graft-related molecules have been identified as correlating with early graft dysfunction and/or poor outcome in the immediate posttransplant period. Also, different inhibitors have been utilized to ameliorate the preservation-induced injury, alone or in combination with different preservation solutions. SUMMARY: Preservation-induced injury is a major contributing factor to early graft dysfunction in organ recipients. The success of organ transplantation is critically dependent on the quality of the donor organ. Donor-organ quality, in turn, is determined by a variety of factors, including donor age, donor management prior to organ procurement, the duration of hypothermic storage, and perfusion techniques utilized to protect organs from ischemia/reperfusion injury, which in turn cause a dramatic reprogramming of cell metabolism during organ transplantation. The expression of a number of inflammatory genes has been associated with early graft dysfunction and/or poor outcome in the immediate postoperative period. Some therapeutic manipulations have been demonstrated to be of significance in attaining near-normal organ function after transplantation.
Authors: G Sgarbi; F Giannone; G A Casalena; A Baracca; M Baldassare; P Longobardi; P Caraceni; M Derenzini; G Lenaz; D Trerè; Giancarlo Solaini Journal: J Bioenerg Biomembr Date: 2011-10-21 Impact factor: 2.945
Authors: Borggia Seemampillai; Renee Germack; Leanne E Felkin; Ann McCormack; Marlene L Rose Journal: Transplantation Date: 2014-07-15 Impact factor: 4.939