BACKGROUND: Herbal medicines have been used since ancient times as drugs for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity. OBJECTIVE: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-alpha secretion in animal model. METHODS: BALB/c mice were divided into 2 groups with 8 mice: group A (mice administered with Z. multiflora essence intraperitoneally), group B (mice administered with distilled water intraperitoneally).Blood was taken from 4 mice in each group at days 4 and 7 after injection phagocytic activity and TNF- alpha secretion were assayed by chemiluminescence and ELISA methods, respectively. RESULTS: The results of chemiluminescence and ELISA tests showed significant increasing in phagocytic activity and TNF-alpha secretion of group A in compare with control group at days 4 and 7. CONCLUSION: Z. multiflora essence can stimulate remarkably innate immunity function and it may be used to immunize individuals as prophylactic and/or therapeutic adjuvant alone or in combination with other immunostimulatory agents.
BACKGROUND: Herbal medicines have been used since ancient times as drugs for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity. OBJECTIVE: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-alpha secretion in animal model. METHODS: BALB/c mice were divided into 2 groups with 8 mice: group A (mice administered with Z. multiflora essence intraperitoneally), group B (mice administered with distilled water intraperitoneally).Blood was taken from 4 mice in each group at days 4 and 7 after injection phagocytic activity and TNF- alpha secretion were assayed by chemiluminescence and ELISA methods, respectively. RESULTS: The results of chemiluminescence and ELISA tests showed significant increasing in phagocytic activity and TNF-alpha secretion of group A in compare with control group at days 4 and 7. CONCLUSION:Z. multiflora essence can stimulate remarkably innate immunity function and it may be used to immunize individuals as prophylactic and/or therapeutic adjuvant alone or in combination with other immunostimulatory agents.
Authors: Mohammad Moazeni; Sara Larki; Mohammad Jamal Saharkhiz; Ahmad Oryan; Maryam Ansary Lari; Amir Mootabi Alavi Journal: Antimicrob Agents Chemother Date: 2014-07-28 Impact factor: 5.191
Authors: K Zomorodian; M J Saharkhiz; M J Rahimi; A Bandegi; G Shekarkhar; A Bandegani; K Pakshir; A Bazargani Journal: Pharmacogn Mag Date: 2011-01 Impact factor: 1.085