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Literature DB >> 18684914

Thymic emigration: when and how T cells leave home.

Michael A Weinreich¹, Kristin A Hogquist.

Abstract

The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Krüppel-like transcription factor KLF2.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2008 PMID： 18684914 PMCID： PMC2861282 DOI： 10.4049/jimmunol.181.4.2265

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

65 in total

1. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

Authors: Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth Quackenbush; Jenny Xie; James Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; CarolAnn Keohane; Mark Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen Rupprecht; William Parsons; Hugh Rosen
Journal: Science Date: 2002-03-28 Impact factor: 47.728

2. Thymocyte emigration is mediated by active movement away from stroma-derived factors.

Authors: Mark C Poznansky; Ivona T Olszak; Richard H Evans; Zhengyu Wang; Russell B Foxall; Douglas P Olson; Kathryn Weibrecht; Andrew D Luster; David T Scadden
Journal: J Clin Invest Date: 2002-04 Impact factor: 14.808

3. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.

Authors: Tomoo Ueno; Kyoko Hara; Melissa Swope Willis; Mark A Malin; Uta E Höpken; Daniel H D Gray; Kouji Matsushima; Martin Lipp; Timothy A Springer; Richard L Boyd; Osamu Yoshie; Yousuke Takahama
Journal: Immunity Date: 2002-02 Impact factor: 31.745

4. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

Authors: J Derbinski; A Schulte; B Kyewski; L Klein
Journal: Nat Immunol Date: 2001-11 Impact factor: 25.606

5. A thymic precursor to the NK T cell lineage.

Authors: Kamel Benlagha; Tim Kyin; Andrew Beavis; Luc Teyton; Albert Bendelac
Journal: Science Date: 2002-04-19 Impact factor: 47.728

6. Characterization of lymphatic and venous emigrants from the thymus.

Authors: M Miyasaka; R Pabst; L Dudler; M Cooper; K Yamaguchi
Journal: Thymus Date: 1990-08

7. Kinetics of mature T-cell development in the thymus.

Authors: M Egerton; R Scollay; K Shortman
Journal: Proc Natl Acad Sci U S A Date: 1990-04 Impact factor: 11.205

8. A scanning electron-microscopic study of the rat thymus with special reference to cell types and migration of lymphocytes into the general circulation.

Authors: T Ushiki
Journal: Cell Tissue Res Date: 1986 Impact factor: 5.249

9. Kruppel-like factor 2 regulates thymocyte and T-cell migration.

Authors: Corey M Carlson; Bart T Endrizzi; Jinghai Wu; Xiaojie Ding; Michael A Weinreich; Elizabeth R Walsh; Maqsood A Wani; Jerry B Lingrel; Kristin A Hogquist; Stephen C Jameson
Journal: Nature Date: 2006-07-20 Impact factor: 49.962

10. A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage.

Authors: Daniel G Pellicci; Kirsten J L Hammond; Adam P Uldrich; Alan G Baxter; Mark J Smyth; Dale I Godfrey
Journal: J Exp Med Date: 2002-04-01 Impact factor: 14.307

60 in total

1. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.

Authors: Shigetomo Fukuhara; Szandor Simmons; Shunsuke Kawamura; Asuka Inoue; Yasuko Orba; Takeshi Tokudome; Yuji Sunden; Yuji Arai; Kazumasa Moriwaki; Junji Ishida; Akiyoshi Uemura; Hiroshi Kiyonari; Takaya Abe; Akiyoshi Fukamizu; Masanori Hirashima; Hirofumi Sawa; Junken Aoki; Masaru Ishii; Naoki Mochizuki
Journal: J Clin Invest Date: 2012-03-12 Impact factor: 14.808

2. Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5.

Authors: Michael A Weinreich; Stephen C Jameson; Kristin A Hogquist
Journal: J Immunol Date: 2010-12-27 Impact factor: 5.422

3. Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection.

Authors: Ryan J Martinez; Anna B Morris; Dennis K Neeld; Brian D Evavold
Journal: Eur J Immunol Date: 2016-09 Impact factor: 5.532

4. CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus.

Authors: Marc Douaisi; Rachel S Resop; Maho Nagasawa; Joshua Craft; Beth D Jamieson; Bianca Blom; Christel H Uittenbogaart
Journal: J Immunol Date: 2017-02-03 Impact factor: 5.422

5. Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery.

Authors: Rachel S Resop; Marc Douaisi; Joshua Craft; Loes C M Jachimowski; Bianca Blom; Christel H Uittenbogaart
Journal: J Allergy Clin Immunol Date: 2016-04-04 Impact factor: 10.793

10. MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.

Authors: Deborah L Hodge; Della Reynolds; Fabio M Cerbán; Silvia G Correa; Natalia S Baez; Howard A Young; Maria Cecilia Rodriguez-Galan
Journal: Eur J Immunol Date: 2012-08-15 Impact factor: 5.532