OBJECTIVES: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available. METHODS: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT. RESULTS: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased. There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women. CONCLUSION: ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather than volumetric BMD.
OBJECTIVES: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available. METHODS: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT. RESULTS: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased. There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women. CONCLUSION:ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather than volumetric BMD.
Authors: A Rubinacci; D Tresoldi; E Scalco; I Villa; F Adorni; G L Moro; G F Fraschini; G Rizzo Journal: Osteoporos Int Date: 2011-09-24 Impact factor: 4.507
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Authors: Ana M Valdes; Unnur Styrkarsdottir; Michael Doherty; David L Morris; Massimo Mangino; Agu Tamm; Sally A Doherty; Kalle Kisand; Irina Kerna; Ann Tamm; Margaret Wheeler; Rose A Maciewicz; Weiya Zhang; Kenneth R Muir; Elaine M Dennison; Deborah J Hart; Sarah Metrustry; Ingileif Jonsdottir; Gudbjorn F Jonsson; Helgi Jonsson; Thorvaldur Ingvarsson; Cyrus Cooper; Timothy J Vyse; Tim D Spector; Kari Stefansson; Nigel K Arden Journal: PLoS One Date: 2011-08-10 Impact factor: 3.240
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