Detailed probabilistic modelling of cell inactivation by ionizing radiations of different qualities: the model and its applications.

The probabilistic two-stage model of cell killing by ionizing radiation enables to represent both damage induction by radiation and its repair by the cell. The model properties and applications as well as possible interpretation of the underlying damage classification are discussed. Analyses of published survival data for V79 hamster cells irradiated by protons and He, C, O, and Ne ions are reported, quantifying the variations in radiation quality with increasing charge and linear energy transfer of the ions.