| Literature DB >> 18684621 |
Richard Berger1, Cheng Zhu, Alexa R Hansen, Bart Harper, Zhesheng Chen, Tom G Holt, James Hubert, Susan J Lee, Jie Pan, Su Qian, Marc L Reitman, Alison M Strack, Drew T Weingarth, Michael Wolff, Douglas J Macneil, Ann E Weber, Scott D Edmondson.
Abstract
The discovery and structure-activity relationship of 1,2-diarylimidazole piperazine carboxamides bearing polar side chains as potent and selective cholecystokinin 1 receptor (CCK1R) agonists are described. Optimization of this series resulted in the discovery of isopropyl carboxamide 40, a CCK1R agonist with sub-nanomolar functional and binding activity as well as excellent potency in a mouse overnight food intake reduction assay.Entities:
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Year: 2008 PMID： 18684621 DOI： 10.1016/j.bmcl.2008.07.083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823