BACKGROUND: Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. METHODS: The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. RESULTS: Group differences in activation magnitude and spatial extent were non-significant. CONCLUSIONS: Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.
BACKGROUND: Functional magnetic resonance imaging (FMRI) studies comparing schizophreniapatients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. METHODS: The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophreniapatient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. RESULTS: Group differences in activation magnitude and spatial extent were non-significant. CONCLUSIONS: Typical smoking histories in schizophreniapatients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.
Authors: Deanna M Barch; Jennifer R Mathews; Randy L Buckner; Luigi Maccotta; John G Csernansky; Abraham Z Snyder Journal: Neuroimage Date: 2003-11 Impact factor: 6.556
Authors: Eric R Cohen; Egill Rostrup; Karam Sidaros; Torben E Lund; Olaf B Paulson; Kamil Ugurbil; Seong-Gi Kim Journal: Neuroimage Date: 2004-10 Impact factor: 6.556
Authors: Faith M Hanlon; Nicholas A Shaff; Andrew B Dodd; Josef M Ling; Juan R Bustillo; Christopher C Abbott; Shannon F Stromberg; Swala Abrams; Denise S Lin; Andrew R Mayer Journal: Hum Brain Mapp Date: 2015-11-24 Impact factor: 5.038
Authors: Claudia E Schneider; Tonya White; Johanna Hass; Daniel Geisler; Stuart R Wallace; Veit Roessner; Daphne J Holt; Vince D Calhoun; Randy L Gollub; Stefan Ehrlich Journal: J Psychiatr Res Date: 2013-12-18 Impact factor: 4.791