Literature DB >> 18683934

Bipleiophylline, an unprecedented cytotoxic bisindole alkaloid constituted from the bridging of two indole moieties by an aromatic spacer unit.

Toh-Seok Kam1, Shin-Jowl Tan, Seik-Weng Ng, Kanki Komiyama.   

Abstract

A cytotoxic bisindole alkaloid possessing an unprecedented structure in which two indole moieties are bridged by an aromatic spacer unit has been isolated from Alstonia angustifolia. The structure was established by analysis of the spectroscopic data and confirmed by X-ray diffraction analysis. A possible biogenetic pathway from pyrocatechuic acid and pleiocarpamine is presented.

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Year:  2008        PMID： 18683934     DOI： 10.1021/ol801354s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings.

Authors:  David Lachkar; Natacha Denizot; Guillaume Bernadat; Kadiria Ahamada; Mehdi A Beniddir; Vincent Dumontet; Jean-François Gallard; Régis Guillot; Karine Leblanc; Elvis Otogo N'nang; Victor Turpin; Cyrille Kouklovsky; Erwan Poupon; Laurent Evanno; Guillaume Vincent
Journal:  Nat Chem       Date:  2017-02-27       Impact factor: 24.427

2.  Exploration of the interrupted Fischer indolization reaction.

Authors:  Alex W Schammel; Ben W Boal; Liansuo Zu; Tehetena Mesganaw; Neil K Garg
Journal:  Tetrahedron       Date:  2010-06-26       Impact factor: 2.457

3.  Pardon the Interruption: A Modification of Fischer's Venerable Reaction for the Synthesis of Heterocycles and Natural Products.

Authors:  Robert B Susick; Lucas A Morrill; Elias Picazo; Neil K Garg
Journal:  Synlett       Date:  2017       Impact factor: 2.454

Review 4.  Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.

Authors:  Md Toufiqur Rahman; Veera V N Phani Babu Tiruveedhula; James M Cook
Journal:  Molecules       Date:  2016-11-14       Impact factor: 4.411

5.  Isochromanoindolenines suppress triple-negative breast cancer cell proliferation partially via inhibiting Akt activation.

Authors:  Xiaoyan Jiang; Xu Zhi; Peixia Zhang; Zhongmei Zhou; Jinxiang Ye; Yu Gao; Xinye Wang; Chuanyu Yang; Haijun Chen; Rong Liu; Ceshi Chen
Journal:  Int J Biol Sci       Date:  2021-03-02       Impact factor: 6.580

Review 6.  Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis.

Authors:  Kamal P Pandey; Md Toufiqur Rahman; James M Cook
Journal:  Molecules       Date:  2021-06-07       Impact factor: 4.411

7.  Monoterpenoid indole alkaloids from Alstonia yunnanensis and their cytotoxic and anti-inflammatory activities.

Authors:  Peng Cao; Yong Liang; Xu Gao; Xiao-Ming Li; Zhen-Quan Song; Guobiao Liang
Journal:  Molecules       Date:  2012-11-16       Impact factor: 4.411
  7 in total

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